Results 261 to 270 of about 100,070 (325)

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

Expressive language and social communication abilities in children with spinal muscular atrophy type 1

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To investigate parent‐reported expressive language and social communication abilities in children with spinal muscular atrophy type 1 (SMA1) treated with disease‐modifying therapies. Method This was a cross‐sectional feasibility study performed at the Dubowitz Neuromuscular Centre, London (UK), and the Centro Clinico Nemo Pediatrico, Rome (
Chiara Brusa, Bianca Buchignani, Chiara Cutri, Giorgia Coratti, Elaine Clark, Emily Johnson, Nikki Cornell, Mariacristina Scoto, Marika Pane, Eugenio Maria Mercuri, Francesco Muntoni, Giovanni Baranello, The Language and Social Communication in SMA working group, Harriet Weststrate, Emily Barritt, Laura Antonaci, Daniela Leone, Concetta Palermo, Pinki Munot, Adnan Manzur   +19 more
wiley   +1 more source

Neuromuscular junction visualization in paraffin-embedded thyroarytenoid muscle sections: Expanding options beyond frozen section analysis. [PDF]

Laryngoscope Investig Otolaryngol
Kaefer SL, Shay EO, Morrison RA, Zhang L, Voytik-Harbin S, Halum S.   +5 more
europepmc   +1 more source

Three‐year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III

Developmental Medicine &Child Neurology, EarlyView.
In this study, we followed a group of children 2 to 6 years old with spastic cerebral palsy functioning in GMFCS levels I–III, over 3 years. Sixty‐five received BoNT‐A and 59 did not. Repeated BoNT‐A injections over 3 years were not associated with improvements in gross motor function or passive ankle dorsiflexion. Daily step counts, favouring the BoNT‐
Darcy Fehlings, Emma Bohn, Lauren Switzer, Charles H. Goldsmith, Unni Narayanan, Peter L. Rosenbaum, F. Virginia Wright, Gary Foster, CP‐BoNT‐A Study Group, Timothy Carey, Mark Mason, Ronit Mesterman   +11 more
wiley   +1 more source

Interaction between neuromuscular junction metabolic requirements in fragile X syndrome and glycogen storage disease models.

Dis Model Mech
Gurijala A, Rushton E, Leahy SN, Nelson N, Tessier CR, Broadie K.   +5 more
europepmc   +1 more source

Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction. [PDF]

Exp Neurol
Hoffman DB, Raymond-Pope CJ, Pritchard EE, Bruzina AS, Lillquist TJ, Corona BT, Call JA, Greising SM.   +7 more
europepmc   +1 more source

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman, Oscar Horwath, Eva Pontén, Sudarshan Dayanidhi, Ferdinand von Walden   +4 more
wiley   +1 more source

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. [PDF]

Nat Commun
Ham AS, Lin S, Tse A, Thürkauf M, McGowan TJ, Jörin L, Oliveri F, Rüegg MA.   +7 more
europepmc   +1 more source

Equine botulism

Equine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy. [PDF]

Cell Death Discov
Ting HC, Guo YT, Su HL, Chen YS, Lin SZ, Harn HJ, Chang CY.   +6 more
europepmc   +1 more source