Results 271 to 280 of about 667,809 (331)

Equine botulism

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik   +2 more
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

open access: yesThe FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés   +19 more
wiley   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

open access: yesThe FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický   +22 more
wiley   +1 more source

Child Psychiatry and Child Neurology Need to Come Together

open access: yes
Acta Paediatrica, EarlyView.
Mary Coleman   +4 more
wiley   +1 more source

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