Results 291 to 300 of about 100,070 (325)

Neuromuscular junction disorders

2016
Diseases of the neuromuscular junction comprise a wide range of disorders. Antibodies, genetic mutations, specific drugs or toxins interfere with the number or function of one of the essential proteins that control signaling between the presynaptic nerve ending and the postsynaptic muscle membrane.
Jan, Verschuuren, Ellen, Strijbos, Angela, Vincent   +2 more
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Targeting neuromuscular junction to treat neuromuscular disorders

Life Sciences, 2023
The integrity and preservation of the neuromuscular junction (NMJ), the interface between the motor neuron and skeletal muscle, is critical for maintaining a healthy skeletal muscle. The structural and/or functional defects in the three cellular components of NMJ, namely the pre-synaptic terminal, synaptic cleft, and post-synaptic region, negatively ...
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Neuromuscular Junction Disordersa

2015
Abstract The neuromuscular junction (NMJ) is a critical component of the motor unit that is made up of the distal, unmyelinated nerve terminal, synaptic space, and end-plate region of the muscle fiber. Contraction of muscle fiber involves a coordinated series of steps that ultimately generates an action potential at the muscle end plate (
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Watching the neuromuscular junction

Journal of Neurocytology, 2003
To understand how synapses form, it is important to be able to watch them as they form. Transgenic mice in which motor axons are indelibly labeled with the Green Fluorescent Protein (GFP) or one of its spectral variants (XFPs) provide a new way to image motor nerve terminals; when combined with contrasting stains for the postsynaptic membrane, both pre-
Jeff W, Lichtman, Joshua R, Sanes
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Gap junctional communication during neuromuscular junction formation

Neuron, 1991
We have tested whether gap junctions form between nerve and muscle during their initial contact, before establishing the chemical synapse. Embryonic Xenopus stage 18-20 myotomes and neural tubes were permeabilized with DMSO to load appropriate reagents, dissociated, and cocultured.
F, Allen, A, Warner
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Neuromuscular Junction

2019
This chapter outlines an introduction to the neuromuscular junction. It covers anatomy and physiology (including presynaptic physiology and pharmacology, postsynaptic physiology and pharmacology, and margin of safety of neurotransmission), paralytics, reversal agents, the mechanisms of action of muscle relaxants (and their structure-activity ...
Christiane G. Stäuble, Heidrun Lewald, Manfred Blobner   +2 more
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The neuromuscular junction

Surgery (Oxford), 2007
Abstract Skeletal muscle fibres are innervated by large, myelinated motor neurons originating in the anterior horn of the spinal cord. The end of each motor axon branches into 20–100 thin terminal fibres, each of which has a terminal unmyelinated zone that innervates a single muscle fibre.
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Neuromuscular junction disorders

2015
Abstract This is a chapter on Neuromuscular junction disorders from the Lower Motor Neuron / Muscle disorders section of A Manual of Neurological Signs. Most of the chapters contain a description of the sign, associated signs, and cases, supported by clinical videos and figures.
John G. Morris, Padraic J. Grattan-Smith
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Neuromuscular Junction Conditions

2015
The key feature of myasthenia gravis is a history of muscle weakness precipitated by activity, termed fatigability.
Ashok Johari, Ratna Maheshwari, Shalin Maheshwari   +2 more
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Neuromuscular Junction

2006
K Sembulingam, Prema Sembulingam
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