Results 321 to 330 of about 667,809 (331)

Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.

Human Molecular Genetics, 2020
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Acetylcholine receptors (AChRs) are restricted at the synaptic region for proper neurotransmission.
Yatao Xiao, Jianmin Zhang, Xiaoqiu Shu, Lei Bai, Wentao Xu, Ailian Wang, Aizhong Chen, Wen-Yo Tu, Jianwen Wang, Kejing Zhang, B. Luo, Chengyong Shen   +11 more
semanticscholar   +1 more source

Neuromuscular Junction Formation, Aging, and Disorders.

Annual Review of Physiology, 2018
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory, perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed between motoneurons and skeletal muscle fibers that is covered by Schwann ...
Lei Li, W. Xiong, L. Mei
semanticscholar   +1 more source

Neuromuscular Junction

Oxford Textbook of Neuroscience and Anaesthesiology, 2019
This chapter outlines an introduction to the neuromuscular junction. It covers anatomy and physiology (including presynaptic physiology and pharmacology, postsynaptic physiology and pharmacology, and margin of safety of neurotransmission), paralytics ...
C. G. Stäuble, Heidrun Lewald, M. Blobner   +2 more
semanticscholar   +1 more source

Muscle Expression of SOD1G93A Triggers the Dismantlement of Neuromuscular Junction via PKC-Theta.

Antioxidants and Redox Signaling, 2017
AIM Neuromuscular junction (NMJ) represents the morphofunctional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and amyotrophic lateral sclerosis, display altered
G. Dobrowolny, M. Martini, B. M. Scicchitano, V. Romanello, S. Boncompagni, C. Nicoletti, L. Pietrangelo, S. De Panfilis, A. Catizone, M. Bouché, M. Sandri, R. Rudolf, F. Protasi, A. Musarò   +13 more
semanticscholar   +1 more source

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

Physiological Reviews, 2015
The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential from the presynaptic motor neuron into the contraction of the postsynaptic muscle fiber. Diseases
L. Tintignac, H. Brenner, M. Rüegg
semanticscholar   +1 more source

Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis

Molecular Neurobiology, 2022
Sagar Verma, Shiffali Khurana, A. Vats, Bandana Sahu, N. Ganguly, Pradip Chakraborti, M. Gourie‐Devi, V. Taneja   +7 more
semanticscholar   +1 more source

Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders

Lancet Neurology, 2022
A. Punga, P. Maddison, J. Heckmann, J. Guptill, A. Evoli   +4 more
semanticscholar   +1 more source

Congenital myasthenic syndromes and the neuromuscular junction.

Current Opinion in Neurology, 2014
PURPOSE OF REVIEW Congenital myasthenic syndromes (CMS) are a group of heterogeneous inherited disorders caused by mutations in genes encoding proteins essential for the integrity of neuromuscular transmission.
P. M. Rodríguez Cruz, Jacqueline Palace, D. Beeson   +2 more
semanticscholar   +1 more source