Results 81 to 90 of about 2,616,272 (289)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Sugammadex and Acceleromyography Used During a Lensectomy in a Sea Lion (Zalophus californianus)

Animals
Neuromuscular blocking agents (NMBAs) are essential in intraocular surgeries to improve surgical conditions and ensure optimal ventilation. However, residual blockade can pose significant risks, particularly in pinnipeds due to their unique diving ...
Magdalena Nowak, Shawn Johnson, Claire Simeone, Rocio Canales, Eduardo Huguet-Baudin, Martina Mosing   +5 more
doaj   +1 more source

U.S. Census Monitoring Board: Congressional Members

, 1998
info:ark/67531/metadc797Congress established the Census Monitoring Board to observe and monitor all aspects of the preparation and implementation of the 2000 decennial census.
U.S. Census Monitoring Board
core  

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

Comparison of kinemyography and electromyography during onset of and recovery from non-depolarising neuromuscular blockade: prospective observational study

Anaesthesiology Intensive Therapy
Background Quantitative neuromuscular monitoring is essential for the safe management of neuromuscular blockade. Although electromyography (EMG) is increasingly regarded as a reference technique, kinemyography (KMG) remains widely used in clinical ...
Michal Kalina, Jan Beneš, Olha Litvina, Vladimír Černý   +3 more
doaj   +1 more source

Intraoperative Neurophysiological Monitoring and Neuromuscular Anesthesia Depth Monitoring

Korean Journal of Clinical Laboratory Science, 2020
Deep blocking of consciousness alone does not prevent a reaction to severe stimuli, and copious amounts of pain medication do not guarantee unconsciousness.
Sang-Hun Kim, Soon-Bu Park, Hyo-Chan Kang, Sang-Ku Park   +3 more
doaj   +1 more source

Acoustic Monitoring of Intraoperative Neuromuscular Block

Survey of Anesthesiology, 1999
Standard methods for accurate intraoperative measurement of neuromuscular block are either expensive or inconvenient and are not used widely. We have evaluated a new method of monitoring neuromuscular block using a low-frequency microphone. The method is based on the phenomenon of low-frequency sound emission by contracting skeletal muscle.
A, Dascalu, E, Geller, Y, Moalem, M, Manoah, S, Enav, Z, Rudick   +5 more
openaire   +2 more sources

DEVELOPMENT AND CHARACTERIZATION OF A NEUROMUSCULAR IN VITRO MODEL DERIVED FROM HUMAN PLURIPOTENT STEM CELLS

, 2022
reservedPer sviluppare un modello di muscolo scheletrico umano in vitro, in grado di riprodurre la variabilità paziente-specifica, le cellule staminali umane pluripotenti indotte sono una interessante opzione. In primo luogo, lo studio si è focalizzato
BRAGGION, MARCO
core  

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source