Results 121 to 130 of about 685 (145)

Use of nondepolarizing neuromuscular blocking agents in mechanically ventilated patients.

Clinical pharmacy, 1991
The pharmacology and history of development of nondepolarizing neuromuscular blocking agents are presented, and the pharmacokinetics and pharmacodynamics of these agents, administration guidelines for mechanically ventilated patients, adverse effects, factors affecting paralysis, and methods for blockade reversal are reviewed.
M L, Buck, M D, Reed
openaire   +1 more source

Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels

Critical Care Medicine, 2000
Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, and an increasing number of patients with acute quadriplegic myopathy have been reported with increased use of these drugs.
L, Larsson, X, Li, L, Edström, L I, Eriksson, H, Zackrisson, C, Argentini, S, Schiaffino   +6 more
openaire   +3 more sources

Intraoperative Use of Nondepolarizing Neuromuscular Blocking Agents During Cardiac Surgery and Postoperative Pulmonary Complications: A Prospective Randomized Trial

Journal of Cardiothoracic and Vascular Anesthesia, 2019
Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating ...
Rebecca M. Gerlach, Sajid Shahul, Kristen E. Wroblewski, Elizabeth K.H. Cotter, Blake W. Perkins, John-Henry Harrison, Takeyoshi Ota, Valluvan Jeevanandam, Mark A. Chaney   +8 more
openaire   +2 more sources

Intermediate-Acting Nondepolarizing Neuromuscular Blocking Agents and Risk of Postoperative 30-Day Morbidity and Mortality, and Long-term Survival

Anesthesia & Analgesia, 2017
BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality ...
Michael R, Bronsert, William G, Henderson, Terri G, Monk, Joshua S, Richman, Jennifer D, Nguyen, John T, Sum-Ping, Michael P, Mangione, Binh, Higley, Karl E, Hammermeister   +8 more
openaire   +2 more sources

Pharmacology of G‐1–64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action

Acta Anaesthesiologica Scandinavica, 1999
Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we ...
L, Gyermek, C, Lee, N, Nguyen
openaire   +2 more sources

Long-acting nondepolarizing neuromuscular blocking agents.

AANA journal, 1993
Patients with compromised cardiovascular function who are undergoing cardiothoracic or other lengthy surgical procedures are at risk of complications from the hemodynamic effects of the long-acting nondepolarizing neuromuscular blocking agents (NMBs), which have been in use for several decades.
openaire   +1 more source

A Retrospective Analysis of Long‐Term Use of Nondepolarizing Neuromuscular Blocking Agents in the Intensive Care Unit, and Guidelines for Drug Selection

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1993
Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
D M, Clarens, K J, Kelly, S S, Gilliland, P K, Kohls, A, Nahum, K, Vance-Bryan   +5 more
openaire   +2 more sources

The role of nondepolarizing neuromuscular blocking agents in mechanically ventilated patients.

Journal of the Medical Association of Georgia, 1995
Prolonged use of the nondepolarizing neuromuscular blocking agents in the critical care setting has greatly increased in the recent past. Accompanying the increased use of these agents are numerous accounts of long-lasting adverse outcomes such as muscular atrophy and neuropathy that can be attributed to pharmacologic paralysis.
J R, May, A F, Rutkowski
openaire   +1 more source

Vecuronium: A New Nondepolarizing Neuromuscular‐Blocking Agent; Clinical Pharmacology, Pharmacokinetics, Cardiovascular Effects and Use in Special Clinical Situations

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1984
Vecuronium provides additional flexibility to the clinician using neuromuscular‐blocking drugs. Its shorter duration of action, lack of significant cardiovascular effects and lack of dependence on the kidney for elimination provide clinical advantages over, or alternatives to, currently available, nondepolarizing neuromuscular‐blocking drugs.
openaire   +2 more sources

THE PHARMACOLOGY OF NEW SHORT-ACTING NONDEPOLARIZING ESTER NEUROMUSCULAR BLOCKING AGENTS

Survey of Anesthesiology, 1973
J J, Savarese, S, Ginsburg, S M, Lee, R J, Kitz   +3 more
openaire   +2 more sources