Results 141 to 150 of about 1,304 (177)
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Resistance to Nondepolarizing Neuromuscular Blocking Agents
Pharmacotherapy, 1996Several case reports of resistance to short‐term administration of nondepolarizing neuromuscular blocking agents (NNMBAs) have been reported in research and surgical settings. Recently, several reports documented resistance to NNMBAs during therapy for prolonged paralysis in critically ill patients. Adverse outcomes associated with NNMBA resistance may
S J, Tschida +3 more
exaly +3 more sources
Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine
Journal of Critical Care, 2009It has been almost 20 years since the introduction of the last new nondepolarizing neuromuscular blocking agent into clinical practice, and research is ongoing to fill a clinical need for a nondepolarizing agent with a fast onset of effect and a short duration of action, as described by Savarese and Kitz [1] in 1975.
Cynthia A Lien, John J Savarese
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The Quest for a Short‐Acting Nondepolarizing Neuromuscular Blocking Agent
Acta Anaesthesiologica Scandinavica, 1974Current developments in the pharmacology of neuromuscular blocking agents indicate that within the next several years, nondepolarizing drugs of short and intermediate duration of action, devoid of significant side effects, may become a reality. The important factors which may permit their development are reviewed.
J J, Savarese, R J, Kitz
exaly +3 more sources
Seminars in Anesthesia, 2002
T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
Leo H D J Booij, Jan van Egmond
exaly +2 more sources
T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
Leo H D J Booij, Jan van Egmond
exaly +2 more sources
Journal of Anesthesia, 2000
The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman ...
Yasuhiko Hashimoto +2 more
exaly +3 more sources
The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman ...
Yasuhiko Hashimoto +2 more
exaly +3 more sources
Pharmacotherapy, 1996
Guidelines for selecting nondepolarizing neuromuscular blocking agents (NNMBAs) were developed and implemented by an interdisciplinary team for use in our intensive care units. They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. If either of these criteria is not met and hepatic
Kyle Vance-Bryan
exaly +3 more sources
Guidelines for selecting nondepolarizing neuromuscular blocking agents (NNMBAs) were developed and implemented by an interdisciplinary team for use in our intensive care units. They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. If either of these criteria is not met and hepatic
Kyle Vance-Bryan
exaly +3 more sources
Anesthesiology, 2001
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
Richard Robitaille +2 more
exaly +3 more sources
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
Richard Robitaille +2 more
exaly +3 more sources
Anesthesiology, 2014
AbstractBackground:We tested the hypothesis that neostigmine reversal of neuromuscular blockade reduced the incidence of signs and symptoms of postoperative respiratory failure.Methods:We enrolled 3,000 patients in this prospective, observer-blinded, observational study.
Matthew J Meyer +2 more
exaly +3 more sources
AbstractBackground:We tested the hypothesis that neostigmine reversal of neuromuscular blockade reduced the incidence of signs and symptoms of postoperative respiratory failure.Methods:We enrolled 3,000 patients in this prospective, observer-blinded, observational study.
Matthew J Meyer +2 more
exaly +3 more sources
Journal of Cardiothoracic and Vascular Anesthesia, 2019
Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating ...
Rebecca M Gerlach +2 more
exaly +3 more sources
Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating ...
Rebecca M Gerlach +2 more
exaly +3 more sources
Pharmacotherapy, 1993
Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
D M, Clarens +5 more
exaly +3 more sources
Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
D M, Clarens +5 more
exaly +3 more sources