Results 151 to 160 of about 1,304 (177)
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Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery After Administration of Nondepolarizing Neuromuscular Blocking Agents

World Journal of Surgery, 2009
AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
Koung-Shing, Chu   +7 more
openaire   +2 more sources

Org. 6368: a nondepolarizing neuromuscular blocking agent with a novel effect on end-plate conductance.

The Journal of Pharmacology and Experimental Therapeutics, 1984
The effects of the nondepolarizing agent pancuronium and three derivatives on end-plate currents (e.p.c.s), evoked by neural stimulation at the amphibian neuromuscular junction, were investigated using conventional voltage clamp techniques. All four agents depressed peak e.p.c.
N N, Durant, R, Horn
openaire   +2 more sources

Potential Clinical Uses of Short-Acting Nondepolarizing Neuromuscular-Blocking Agents as Predicted from Animal Experiments

Anesthesia & Analgesia, 1975
It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents.
J J, Savarese, R P, Antonio, S, Ginsburg
openaire   +2 more sources

Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels

Critical Care Medicine, 2000
Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, and an increasing number of patients with acute quadriplegic myopathy have been reported with increased use of these drugs.
L, Larsson   +6 more
openaire   +3 more sources

Pharmacology of G‐1–64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action

Acta Anaesthesiologica Scandinavica, 1999
Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we ...
L, Gyermek, C, Lee, N, Nguyen
openaire   +2 more sources

Use of nondepolarizing neuromuscular blocking agents in mechanically ventilated patients.

Clinical pharmacy, 1991
The pharmacology and history of development of nondepolarizing neuromuscular blocking agents are presented, and the pharmacokinetics and pharmacodynamics of these agents, administration guidelines for mechanically ventilated patients, adverse effects, factors affecting paralysis, and methods for blockade reversal are reviewed.
M L, Buck, M D, Reed
openaire   +1 more source

Intermediate-Acting Nondepolarizing Neuromuscular Blocking Agents and Risk of Postoperative 30-Day Morbidity and Mortality, and Long-term Survival

Anesthesia & Analgesia, 2017
BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality ...
Michael R, Bronsert   +8 more
openaire   +2 more sources

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