Results 161 to 170 of about 1,828 (217)
Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids
Muscle & Nerve, 1994 AbstractThe long‐term use of nondepolarizing neuromuscular blocking agents (ND‐NMBA) has recently been implicated as a cause of prolonged muscle weakness, although the site of the lesion and the predisposing factors have been unclear. We report 3 patients (age 37–52 years) with acute respiratory insufficiency who developed prolonged weakness following ...
Richard J. Barohn +4 more
openalex +3 more sources
The Quest for a Short‐Acting Nondepolarizing Neuromuscular Blocking Agent
Acta Anaesthesiologica Scandinavica, 1974 Current developments in the pharmacology of neuromuscular blocking agents indicate that within the next several years, nondepolarizing drugs of short and intermediate duration of action, devoid of significant side effects, may become a reality. The important factors which may permit their development are reviewed.
John J. Savarese, Richard J. Kitz
openalex +3 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996 Guidelines for selecting nondepolarizing neuromuscular blocking agents (NNMBAs) were developed and implemented by an interdisciplinary team for use in our intensive care units. They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. If either of these criteria is not met and hepatic
Suzanne J. Tschida +2 more
openalex +3 more sources
World Journal of Surgery, 2009 AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
Koung‐Shing Chu +7 more
openalex +3 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1984 The effects of the nondepolarizing agent pancuronium and three derivatives on end-plate currents (e.p.c.s), evoked by neural stimulation at the amphibian neuromuscular junction, were investigated using conventional voltage clamp techniques. All four agents depressed peak e.p.c.
N. N. Durant, R Horn
openalex +3 more sources
Seminars in Anesthesia, Perioperative Medicine and Pain, 2002 T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
L.H.D.J. Booij +2 more
openalex +2 more sources
Long-acting nondepolarizing neuromuscular blocking agents.
AANA journal, 1993 Patients with compromised cardiovascular function who are undergoing cardiothoracic or other lengthy surgical procedures are at risk of complications from the hemodynamic effects of the long-acting nondepolarizing neuromuscular blocking agents (NMBs), which have been in use for several decades.
Embree Pb
openalex +2 more sources
Use of nondepolarizing neuromuscular blocking agents in mechanically ventilated patients.
Clinical pharmacy, 1991 The pharmacology and history of development of nondepolarizing neuromuscular blocking agents are presented, and the pharmacokinetics and pharmacodynamics of these agents, administration guidelines for mechanically ventilated patients, adverse effects, factors affecting paralysis, and methods for blockade reversal are reviewed.
Marcia L. Buck, Michael D. Reed
openalex +2 more sources
Anesthesia & Analgesia, 1975 It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents.
John J. Savarese +2 more
openalex +3 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1993 Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
Diann M. Ciarens +5 more
openalex +3 more sources