Results 61 to 70 of about 123 (105)
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Nondepolarizing Neuromuscular Blocking Agents
2017Neuromuscular blocking medications are an important part of the anesthetic management of many patients undergoing surgery. These drugs act at the neuromuscular junction on postsynaptic acetylcholine receptors. Muscle relaxants can be divided into depolarizing and nondepolarizing categories. Succinylcholine is the only depolarizing neuromuscular blocker
Erin Bettendorf, Zhiling Xiong
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Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia
Anesthesiology, 2016Abstract Background Residual postoperative paralysis from nondepolarizing neuromuscular blocking agents (NMBAs) is a known problem. This paralysis has been associated with impaired respiratory function, but the clinical significance remains unclear.
Catherine Bulka
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Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine
Journal of Critical Care, 2009It has been almost 20 years since the introduction of the last new nondepolarizing neuromuscular blocking agent into clinical practice, and research is ongoing to fill a clinical need for a nondepolarizing agent with a fast onset of effect and a short duration of action, as described by Savarese and Kitz [1] in 1975.
Cynthia A, Lien +4 more
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The Quest for a Short‐Acting Nondepolarizing Neuromuscular Blocking Agent
Acta Anaesthesiologica Scandinavica, 1974Current developments in the pharmacology of neuromuscular blocking agents indicate that within the next several years, nondepolarizing drugs of short and intermediate duration of action, devoid of significant side effects, may become a reality. The important factors which may permit their development are reviewed.
J J, Savarese, R J, Kitz
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Seminars in Anesthesia, 2002
T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
Leo H D J Booij
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T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
Leo H D J Booij
exaly +2 more sources
Anesthesiology, 2014
AbstractBackground:We tested the hypothesis that neostigmine reversal of neuromuscular blockade reduced the incidence of signs and symptoms of postoperative respiratory failure.Methods:We enrolled 3,000 patients in this prospective, observer-blinded, observational study.
Matthias Eikermann, Matthew Meyer
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AbstractBackground:We tested the hypothesis that neostigmine reversal of neuromuscular blockade reduced the incidence of signs and symptoms of postoperative respiratory failure.Methods:We enrolled 3,000 patients in this prospective, observer-blinded, observational study.
Matthias Eikermann, Matthew Meyer
exaly +3 more sources
Anesthesiology, 2001
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
François Donati
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Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
François Donati
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World Journal of Surgery, 2009
AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
Che-Wei Wu, I Cheng Lu, Feng-Yu Chiang
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AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
Che-Wei Wu, I Cheng Lu, Feng-Yu Chiang
exaly +3 more sources
Journal of Anesthesia, 2000
The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman ...
Yasuhiko Hashimoto, Hiroyuki Yamanaka
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The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman ...
Yasuhiko Hashimoto, Hiroyuki Yamanaka
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An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents
Journal of Pharmacokinetics and Pharmacodynamics, 1981A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium ...
A D'Hollander
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