Results 1 to 10 of about 97,622 (334)

Brain derived neurotrophic factor/tropomyosin related kinase B signaling impacts diaphragm neuromuscular transmission in a novel rat chemogenetic model [PDF]

Frontiers in Cellular Neuroscience, 2022
The neuromuscular junction (NMJ) mediates neural control of skeletal muscle fibers. Neurotrophic signaling, specifically brain derived neurotrophic factor (BDNF) acting through its high-affinity tropomyosin related kinase B (TrkB) receptor is known to ...
Matthew J. Fogarty, Matthew J. Fogarty, Obaid U. Khurram, Obaid U. Khurram, Carlos B. Mantilla, Carlos B. Mantilla, Gary C. Sieck, Gary C. Sieck   +7 more
doaj   +2 more sources

Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset. [PDF]

PLoS ONE, 2013
Amyotrophic lateral sclerosis is characterized by a progressive degeneration of the corticospinal tract motor neurons. Growing evidence suggests that degeneration may begin at the distal axon proceeding in a dying-back pattern.
Mariana C Rocha, Paula A Pousinha, Alexandra M Correia, Ana M Sebastião, Joaquim A Ribeiro   +4 more
doaj   +3 more sources

Falsely increased Bispectral Index™ due to neuromuscular transmission monitoring. [PDF]

Anaesth Rep, 2023
Katerenchuk V, Calçada A, Batista AC, Cordeiro L.   +3 more
europepmc   +3 more sources

Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex. [PDF]

Front Synaptic Neurosci, 2021
Martínez-Valencia A, Ramírez-Santiago G, De-Miguel FF.   +2 more
europepmc   +3 more sources

Neuromuscular transmission monitoring using acceleromyography in a patient with Charcot-Marie-Tooth disease. [PDF]

Anesth Pain Med (Seoul)
Ishido H, Iseki Y, Yoshida K, Murakawa M.   +3 more
europepmc   +3 more sources

Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis [PDF]

BMC Pharmacology and Toxicology
Background Myasthenia gravis is a rare autoimmune disease mediated by autoantibodies directed against acetylcholine receptors (AChRs) at the neuromuscular junction.
Baehyun Shin, Monica Wang, John Yim, Elisa Kwon, Margaret H. Magdesian, Camil E. Sayegh, Jason E. Ekert, Douangsone D. Vadysirisack   +7 more
doaj   +2 more sources

Cholesterol and the Safety Factor for Neuromuscular Transmission. [PDF]

Int J Mol Sci, 2019
Krivoi II, Petrov AM.
europepmc   +3 more sources

Long Term Follow-Up on Pediatric Cases With Congenital Myasthenic Syndromes—A Retrospective Single Centre Cohort Study

Frontiers in Human Neuroscience, 2020
Introduction: Congenital myasthenic syndromes (CMS) refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild symptoms to life-limiting forms ...
Adela Della Marina, Eva Wibbeler, Angela Abicht, Angela Abicht, Heike Kölbel, Hanns Lochmüller, Hanns Lochmüller, Hanns Lochmüller, Andreas Roos, Ulrike Schara   +9 more
doaj   +1 more source

The eccentric mechanotransduction, neuro-muscular transmission, and structural reversibility of muscle fatty infiltration. An experimental advanced disuse muscle-wasting model of rabbit supraspinatus

Archives of Medical Science, 2021
Introduction Full-thickness rotator cuff tear is present in almost 50% of patients over age 65 years, and its degree is known to be a good predictor of the severity of muscle-wasting (MW) sarcopaenia, also known as fatty degeneration (FD). A FD CT grade >
Jarosław Fabiś, Marian Danilewicz, Kryspin R. Niedzielski, Michał Waszczykowski, Anna Fabiś-Strobin, Andrzej Bogucki   +5 more
doaj   +1 more source

Development of abnormalities at the neuromuscular junction in the SOD1-G93A mouse model of ALS: dysfunction then disruption of postsynaptic structure precede overt motor symptoms

Frontiers in Molecular Neuroscience, 2023
IntroductionThe ultimate deficit in amyotrophic lateral sclerosis (ALS) is neuromuscular junction (NMJ) loss, producing permanent paralysis, ultimately in respiratory muscles. However, understanding the functional and structural deficits at NMJs prior to
Jayne McIntosh, Imane Mekrouda, Maryam Dashti, Claudiu V. Giuraniuc, Robert W. Banks, Gareth B. Miles, Guy S. Bewick   +6 more
doaj   +1 more source