Results 271 to 280 of about 97,622 (334)

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

open access: yesExperimental Physiology, EarlyView.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon   +2 more
wiley   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

open access: yesExperimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti   +6 more
wiley   +1 more source

Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice.

open access: yesAm J Physiol Gastrointest Liver Physiol, 2019
Perez-Medina AL, Galligan JJ.
europepmc   +1 more source

NEX4EX – A novel exercise device enabling resistive, plyometric and sensorimotor training during deep‐space missions: A case report

open access: yesExperimental Physiology, EarlyView.
Abstract During weightlessness, the human neuro–muscular–skeletal system undergoes maladaptation to the microgravity environment. The European Space Agency (ESA) project NEX4EX, ‘Novel Exercise Hardware for Exploration’, developed an advanced multipurpose exerciser offering resistive (RES), plyometric (PLYO) and sensorimotor (SENSO) exercises.
Jonas Böcker   +7 more
wiley   +1 more source

Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue

open access: yesExperimental Physiology, EarlyView.
Abstract Expiratory flow limitation results in dynamic hyperinflation, dyspnoea and premature exercise intolerance. We aimed to measure whether expiratory resistance reduces locomotor power via limiting maximal voluntary motor activity, exacerbating muscle fatigue, or both.
Jonathan Cunha   +4 more
wiley   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

open access: yesExperimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova   +6 more
wiley   +1 more source

Use of transcutaneous spinal cord stimulation to explore inhibitory and facilitatory circuits in muscles of the human lower limb

open access: yesExperimental Physiology, EarlyView.
Abstract The aim of this study was to explore the primary afferent depolarization mechanism, to determine whether the soleus transspinal evoked potential (TEP), elicited through transcutaneous spinal cord stimulation over the L1–L2 level, is modulated by presynaptic inhibition and heteronymous facilitation, similar to the Hoffmann (H) reflex, elicited ...
Julia Sordet   +5 more
wiley   +1 more source

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