Results 121 to 130 of about 311,459 (229)

Update on biomarkers in neuromyelitis optica

, 2015
Neuromyelitis optica (NMO) (and NMO spectrum disorder) is an autoimmune inflammatory disease of the CNS primarily affecting spinal cord and optic nerves.
Sato, DK, Bar-Or, A, Saiz, A, Pandit, L, Hooper, DC, Bennett, JL, John, GR, Kim, HJ, Asgari, N, Levy, M, Broadley, SA, Waters, PJ, Leite, MI, Melamed, E, et al.   +14 more
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Walsh & Hoyt: Neuromyelitis Optica (Devic\u27s Disease)

, 2005
The association of acute or subacute loss of vision in one or both eyes caused by acute optic neuropathy preceded or followed within days to weeks by a transverse or ascending myelitis was initially described by Allbutt in 1870 and later by Devic, who ...
Laura J. Balcer, MD
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Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 625-634, September 2026.
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi, Makoto Saito, Kazuya Okushin, Toshiyuki Kishida, Akira Kado, Kyoji Moriya, Kazuhiko Koike, Takeya Tsutsumi, Hiroshi Yotsuyanagi   +8 more
wiley   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Detection of anti-aquaporin-4 autoantibodies in the sera of Chinese neuromyelitis optica patients.

, 2013
In this study, we recruited 10 neuromyelitis optica patients, two multiple sclerosis patients and two myelitis patients. Chinese hamster lung fibroblast (V79) cells transfected with a human aquaporin-4-mCherry fusion protein gene were used to detect anti-
PISANI, FRANCESCO, FRIGERI, Antonio, Wang J, Li M, Su W, Ma T.   +5 more
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Physiologically Based Pharmacokinetic Modeling to Predict Human Starting Dose and Pharmacokinetics for Rocbrutinib

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Rocbrutinib is a fourth‐generation Bruton's tyrosine kinase (BTK) inhibitor that covalently binds wild‐type BTK and non‐covalently engages the C481S mutant. Its pharmacokinetic (PK) characteristics in healthy Chinese subjects remain unclear. This study aimed to support maximum recommended starting dose (MRSD) selection and predict exposure of ...
Lu Wang, Dandan Yang, Rong Shao, Jinliang Chen, Xiaodan Wang, Zheng Wang, Bo Jiang   +6 more
wiley   +1 more source

Neuromyelitis Optica. Case Report [PDF]

Revista Ciencias de la Salud, 2009
Neuromyelitis Optica, also known as Devic’sSyndrome, is a disease which combines opticneuritis and transverse myelitis. Some years ago it was considered as a form of multiple sclerosis.Actually, it is consider as a different disease, onthe basis of the ...
Patricia Quintero Cusguen, Ángela María Gutiérrez Álvarez   +1 more
doaj  

Practical Guidance on Initiating and Switching Targeted Immunotherapies in Generalised Myasthenia Gravis: A German–Austrian Expert Opinion Paper

European Journal of Neurology, Volume 33, Issue 9, September 2026.
ABSTRACT Background The therapeutic landscape of generalised myasthenia gravis (gMG) has evolved substantially with the approval of targeted immunotherapies, including complement C5 inhibitors (C5‐I) and neonatal Fc receptor inhibitors (FcRn‐I). While pivotal trials have demonstrated marked efficacy in defined subgroups, real‐world experience reveals ...
Andreas Meisel, Adela Della Marina, Paolo Doksani, Tim Hagenacker, Christoph Kleinschnitz, Heidrun H. Krämer, Jan D. Lünemann, Sven G. Meuth, Tobias Ruck, Ulrike Schara‐Schmidt, Christiane Schneider‐Gold, Benedikt Schoser, Michael Schroeter, Charlotte Schubert, Jörn Peter Sieb, Fritz Zimprich, Jana Zschüntzsch, Sarah Hoffmann   +17 more
wiley   +1 more source

Neuromyelitis Optica

, 2015
Power point of case presentation of female with bilateral, sequential atypical optic neuritis. MRI Brain normal with no demyelination; MRI Spine shows enhancement at multiple levels and NMO antibody positive, confirming diagnosis of neuromyelitis optica
Omar Ozgur, MD; Rudrani Banik, MD
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