Results 111 to 120 of about 1,037,185 (302)

Protective effects of Berberine on hippocampal neurons after ischemia in vivo and in vitro

BMC Complementary Medicine and Therapies
Background Apoptosis plays a pivotal role in neuronal death following ischemic brain injury. Berberine (BBR), a natural isoquinoline alkaloid extracted from Coptis chinensis, exhibits multiple biological activities and has shown neuroprotective effects ...
Xiaoying Li, Zhangpei Liu, Longyan Lu, Qizhi Zhong, Yuying Wu, Ying Yang, Zheng Zhang, Zhongshan Shi, Dawei Dong   +8 more
doaj   +1 more source

JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis [PDF]

, 2008
Pneumococcal meningitis is associated with caspase 3-dependent apoptosis of recently post-mitotic immature neurons in the dentate gyrus of the hippocampus.
Hans-Rudolf Widmer, Christen, Stephan, Matthias D. Sury, Widmer, Hans-Rudolf, Leib, Stephen L., Stephan Christen, Agarinis, Claudia, Claudia Agarinis, Stephen L. Leib, Sury, Matthias D., Leib SL, Sury MD, Christen S, Widmer HR, Agarinis C   +14 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Neuronal hypoxia in vitro: Investigation of therapeutic principles of HUCB-MNC and CD133⁺ stem cells

BMC Neuroscience, 2008
Background The therapeutic capacity of human umbilical cord blood mononuclear cells (HUCB-MNC) and stem cells derived thereof is documented in animal models of focal cerebral ischemia, while mechanisms behind the reduction of lesion size and the observed
Emmrich Frank, Naumann Wilfried, Scholz Markus, Stahl Tobias, Hau Susann, Reich Doreen M, Boltze Johannes, Kamprad Manja   +7 more
doaj   +1 more source

Caspase Requirement for Neuronal Apoptosis and Neurodegeneration [PDF]

IUBMB Life, 2000
AbstractThe execution of the apoptotic programme involves a relatively few pathways that converge on activation of the caspase family of proteases. However, increasing evidence indicates that apoptoticlike features can be found also when cells are treated with inhibitors of caspases.
openaire   +2 more sources

A schematic diagram illustrating the potential pathways for gp120 enhancement of neuronal I_A and resultant neuronal apoptosis.

, 2013
A schematic diagram illustrating the potential pathways for gp120 enhancement of neuronal IA and resultant neuronal apoptosis.
Changshui Xu (342355), Huangui Xiong (262059), Jianuo Liu (87698), James Keblesh (342357), Weijin Zang (342358), Lina Chen (87129)   +5 more
core   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Apoptosis in the in Vivo Mammalian Forebrain

Neurobiology of Disease, 2001
Apoptosis is a word originally introduced by Kerr, Wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in nonneuronal cells from various tissues.
Krikor Dikranian, Masahiko J. Ishimaru, Tatyana Tenkova, Joann Labruyere, Y.Q. Qin, Chrysanthy Ikonomidou, John W. Olney   +6 more
doaj   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Exosomes derived from M1-macrophage promote enteric neuronal injury via MMP8-TGF-β pathway

Journal of Advanced Research
Introduction: Enteric neuronal injury significantly contributes to gastrointestinal motility disorders. While macrophages are known to interact closely with enteric neurons and modulate intestinal homeostasis, their specific impact on enteric neuronal ...
Yuqiong Chen, Kai Song, Yi Zheng, Chaoting Lan, Yide Mu, Zuyi Ma, Gen Chen, Yun Zhu, Yongwei Huang, Jiazhang Chen, Shenwei Huang, Qiuming He, Lihua Huang, Xiaoyu Zuo, Fenjie Li, Jixiao Zeng, Huimin Xia, Yan Zhang   +17 more
doaj   +1 more source