Results 51 to 60 of about 176,597 (260)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
NMDA receptor kinetics drive distinct routes to chaotic firing in pyramidal neurons
Frontiers in Computational NeuroscienceIntroductionNeuronal firing patterns emerge from complex interactions between intrinsic membrane properties and synaptic receptor dynamics. N-methyl-D-aspartate (NMDA) receptors critically shape calcium influx and synaptic plasticity through their ...
Mehdi Borjkhani +5 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models
Frontiers in Molecular Neuroscience, 2019 Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability. It is produced by mutation of the Fmr1 gene that encodes for the Fragile Mental Retardation Protein (FMRP), an important RNA-binding protein that regulates the ...
Felipe Bodaleo +8 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances
eLifeCircuit function results from both intrinsic conductances of network neurons and the synaptic conductances that connect them. In models of neural circuits, different combinations of maximal conductances can give rise to similar activity.
Zachary Fournier +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Comparing the dynamics of periodically forced lasers and neurons
New Journal of Physics, 2019 Neuromorphic photonics is a new paradigm for ultra-fast neuro-inspired optical computing that can revolutionize information processing and artificial intelligence systems.
Jordi Tiana-Alsina +2 more
doaj +1 more source
Spontaneous and stimulus-induced coherent states of critically balanced neuronal networks
Physical Review Research, 2020 How the information microscopically processed by individual neurons is integrated and used in organizing the behavior of an animal is a central question in neuroscience.
Takashi Hayakawa, Tomoki Fukai
doaj +1 more source