Results 41 to 50 of about 176,597 (260)
DYNAMICS OF A SINGLE MODEL NEURON [PDF]
International Journal of Bifurcation and Chaos, 1993 The parametrized dynamics of a standard nonlinear model neuron with self-interaction is discussed. For units with a self-excitatory connection a hysteresis effect is observed, and the underlying mechanism is identified as that of a cusp catastrophe. This is true for discrete as well as for continuous dynamics.
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation
Translational PsychiatryLong-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood.
Maureen H. McFadden +7 more
doaj +1 more source
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. [PDF]
PLoS Biology, 2016 Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics.
Michal Cagalinec +12 more
doaj +1 more source
Biological Fluctuations and Neuronal Dynamics.
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1999 「確率共振 (Stochastic Resonance; SR) とは, 非線形なシステムに, あるレベルのノイズを加えたとき, 微少な入力信号に対する応答が最適化されるという現象であり, 近年, 物理学, 工学, 生理学等の広範な自然科学の分野で非常に注目されている. とりわけ神経系におけるSRは, 閾値以下の信号を検出可能にするという点で極めて画期的であり, 1個のニューロンやニューラル・ネットワークの数理モデルにSRを見いだす理論研究, あるいは, 実験動物の神経素子に実際にノイズを加えたり, ヒトの視覚-認知系, 皮膚感覚-認知系におけるSRを調べる実証的研究が行われてきた.
Hidaka, Ichiro, Yamamoto, Yoshiharu
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2014 What happens in our brain when we make a decision? What triggers a neuron to send out a signal? What is the neural code? This textbook for advanced undergraduate and beginning graduate students provides a thorough and up-to-date introduction to the fields of computational and theoretical neuroscience.
Gerstner, Wulfram +3 more
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Model-agnostic neural mean field with a data-driven transfer function
Neuromorphic Computing and EngineeringAs one of the most complex systems known to science, modeling brain behavior and function is both fascinating and extremely difficult. Empirical data is increasingly available from ex vivo human brain organoids and surgical samples, as well as in vivo ...
Alex Spaeth +2 more
doaj +1 more source
Assimilating seizure dynamics. [PDF]
PLoS Computational Biology, 2010 Observability of a dynamical system requires an understanding of its state-the collective values of its variables. However, existing techniques are too limited to measure all but a small fraction of the physical variables and parameters of neuronal ...
Ghanim Ullah, Steven J Schiff
doaj +1 more source