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Neuronal migration and disorders – an update

Current Opinion in Neurobiology, 2021
This review highlights genes, proteins and subcellular mechanisms, recently shown to influence cortical neuronal migration. A current view on mechanisms which become disrupted in a diverse array of migration disorders is presented. The microtubule (MT) cytoskeleton is a major player in migrating neurons.
Francis, Fiona, Cappello, Silvia
openaire   +6 more sources

Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders

Frontiers in Cell and Developmental Biology, 2019
Newborn neurons in developing brains actively migrate from germinal zones to designated regions before being wired into functional circuits. The motility and trajectory of migrating neurons are regulated by both extracellular factors and intracellular ...
Yi-Hsuan Pan, Nan Wu, Xiao-Bing Yuan, Xiao-Bing Yuan   +3 more
doaj   +3 more sources

Prenatal Environment That Affects Neuronal Migration

Frontiers in Cell and Developmental Biology, 2019
Migration of neurons starts in the prenatal period and continues into infancy. This developmental process is crucial for forming a proper neuronal network, and the disturbance of this process results in dysfunction of the brain such as epilepsy. Prenatal
Hye M. Hwang, Hye M. Hwang, Ray Y. Ku, Kazue Hashimoto-Torii, Kazue Hashimoto-Torii   +4 more
doaj   +3 more sources

Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS [PDF]

Experimental and Molecular Medicine
, Whether early exposure to general anesthetics hurts human brain development is still under discussion. Animal studies have documented multiple neurotoxicities of repeated/prolonged exposure to sevoflurane (Sev, a commonly used pediatric anesthetic) at ...
Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rougang Xie, Honghui Mao, Boyang Ren, Bosong Huang, Changhong Shi, Zhicheng Shao, Shengxi Wu, Yazhou Wang, Hui Zhang   +14 more
doaj   +2 more sources

Forces to Drive Neuronal Migration Steps [PDF]

Frontiers in Cell and Developmental Biology, 2020
To establish and maintain proper brain architecture and elaborate neural networks, neurons undergo massive migration. As a unique feature of their migration, neurons move in a saltatory manner by repeating two distinct steps: extension of the leading ...
Takunori Minegishi, Naoyuki Inagaki
doaj   +2 more sources

A vascular perspective on neuronal migration

Mechanisms of Development, 2015
During CNS development and adult neurogenesis, immature neurons travel from the germinal zones towards their final destination using cellular substrates for their migration. Classically, radial glia and neuronal axons have been shown to act as physical scaffolds to support neuroblast locomotion in processes known as gliophilic and neurophilic migration,
Segarra, Marta, Kirchmaier, Bettina C., Acker-Palmer, Amparo   +2 more
openaire   +5 more sources

Neuronal migration defects in the Loa dynein mutant mouse [PDF]

Neural Development, 2011
Background Cytoplasmic dynein and its regulatory proteins have been implicated in neuronal and non-neuronal cell migration. A genetic model for analyzing the role of cytoplasmic dynein specifically in these processes has, however, been lacking.
Ori-McKenney Kassandra M, Vallee Richard B   +1 more
doaj   +2 more sources

Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex

Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex
Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation.
GUI, Chun, ZHANG, Rui, KOGA, Kazuo, TAKAHASHI, Sentaro, SUN, Xue-Zhi, NOUYE, Minoru, MURATA, Yoshiharu   +6 more
openaire   +2 more sources

Spatiotemporal Regulation of Rho GTPases in Neuronal Migration

Cells, 2019
Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation.
Zhenyan Xu, Yuewen Chen, Yu Chen
doaj   +2 more sources

Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias [PDF]

Frontiers in Neuroscience, 2015
Neuronal migration disorders are human (or animal) diseases that result from a disruption in the normal movement of neurons from their original birth site to their final destination during early development. As a consequence, the neurons remain somewhere
Mitsuhiro eKato, Mitsuhiro eKato
doaj   +2 more sources