Results 71 to 80 of about 5,020,863 (306)
Современная терапия психических расстройств, 2019 Ограниченная эффективность стандартнои методики транскраниальнои магнитнои стимуляции (ТМС) в лечении расстроиств депрессивного спектра, индивидуальные различия, с однои стороны, в клинических проявлениях депрессии, с другои в работе неиросетеи, диктуют
Антонович, Б.А. +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Neuronal network models of epileptogenesis [PDF]
Neurosciences, 2017 Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders.
Abdullahi, Aminu T., Adamu, Lawan H.
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Optimization of TiO2 and PMAPTAC Concentrations of a Chemical Humidity Sensing Mechanism
Sensors, 2009 This work aims to achieve an optimization of the TiO2 and PMAPTAC concentrations in a chemical resistive-type humidity sensing mechanism (RHSM). Our idea is based primarily on the modeling of the sensing mechanism.
Samir Barra +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investigation of Signal Transmission Dynamics in Rulkov Neuronal Networks with Q-Learned Pathways
EntropyThe dynamics of signal transmission in neuronal networks remain incompletely understood. In this study, we propose a novel Rulkov neuronal network model that incorporates Q-learning, a reinforcement learning method, to establish efficient signal ...
Mio Kobayashi
doaj +1 more source
Can NMDA Spikes Dictate Computations of Local Networks and Behavior?
Frontiers in Molecular Neuroscience, 2019 Intelligence is the ability to learn appropriate responses to stimuli and the capacity to master new skills. Synaptic integration at the dendritic level is thought to be essential for this ability through linear and non-linear processing, by allowing ...
Elisabete Augusto, Frédéric Gambino
doaj +1 more source