Results 51 to 60 of about 276,634 (267)

Noisy Neurons, Neat Networks [PDF]

Neuron, 2015
In this issue of Neuron, Kiani et al. (2015) show that the correlated activity of multiple simultaneously recorded neurons can be used to identify, in a completely un-biased manner, distinct functional domains within prefrontal and (pre)motor cortex of macaque monkeys.
Vanduffel, Wim, Arsenault, John T.
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Spike-Timing-Dependent Plasticity With Axonal Delay Tunes Networks of Izhikevich Neurons to the Edge of Synchronization Transition With Scale-Free Avalanches

Frontiers in Systems Neuroscience, 2019
Critical brain hypothesis has been intensively studied both in experimental and theoretical neuroscience over the past two decades. However, some important questions still remain: (i) What is the critical point the brain operates at?
Mahsa Khoshkhou, Afshin Montakhab
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology

Frontiers in Neuroscience, 2019
Neuroengineering methods can be effectively used in the design of new approaches to treat central nervous system and brain injury caused by neurotrauma, ischemia, or neurodegenerative disorders.
Kenta Shimba, Chih-Hsiang Chang, Takahiro Asahina, Fumika Moriya, Kiyoshi Kotani, Yasuhiko Jimbo, Arseniy Gladkov, Arseniy Gladkov, Oksana Antipova, Yana Pigareva, Vladimir Kolpakov, Irina Mukhina, Irina Mukhina, Victor Kazantsev, Alexey Pimashkin, Alexey Pimashkin   +15 more
doaj   +1 more source

Optimisation & Generalisation in Networks of Neurons

CoRR, 2022
PhD ...
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Нейронные сети состояния покоя при депрессиях и перспективы применения персонифицированной транскраниальной магнитной стимуляции

Современная терапия психических расстройств, 2019
Ограниченная эффективность стандартнои методики транскраниальнои магнитнои стимуляции (ТМС) в лечении расстроиств депрессивного спектра, индивидуальные различия, с однои стороны, в клинических проявлениях депрессии, с другои в работе неиросетеи, диктуют
Антонович, Б.А., Майорова, Л.А., Цукарзи, Э.Э., Мосолов, С.Н.   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source