Results 61 to 70 of about 276,634 (267)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Optimization of TiO2 and PMAPTAC Concentrations of a Chemical Humidity Sensing Mechanism
Sensors, 2009 This work aims to achieve an optimization of the TiO2 and PMAPTAC concentrations in a chemical resistive-type humidity sensing mechanism (RHSM). Our idea is based primarily on the modeling of the sensing mechanism.
Samir Barra +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investigation of Signal Transmission Dynamics in Rulkov Neuronal Networks with Q-Learned Pathways
EntropyThe dynamics of signal transmission in neuronal networks remain incompletely understood. In this study, we propose a novel Rulkov neuronal network model that incorporates Q-learning, a reinforcement learning method, to establish efficient signal ...
Mio Kobayashi
doaj +1 more source
Can NMDA Spikes Dictate Computations of Local Networks and Behavior?
Frontiers in Molecular Neuroscience, 2019 Intelligence is the ability to learn appropriate responses to stimuli and the capacity to master new skills. Synaptic integration at the dendritic level is thought to be essential for this ability through linear and non-linear processing, by allowing ...
Elisabete Augusto, Frédéric Gambino
doaj +1 more source
Influence of Delayed Conductance on Neuronal Synchronization
Frontiers in Physiology, 2020 In the brain, the excitation-inhibition balance prevents abnormal synchronous behavior. However, known synaptic conductance intensity can be insufficient to account for the undesired synchronization. Due to this fact, we consider time delay in excitatory
Paulo R. Protachevicz +18 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Assembly and Connection of Micropatterned Single Neurons for Neuronal Network Formation
Micromachines, 2018 Engineering of neuronal network geometry by micropatterning technology is a key future technology for creating artificial brains on a chip. However, engineering of network geometry at the single-cell-level with functional morphology (axon/dendrite) and ...
Shotaro Yoshida +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source