Results 31 to 40 of about 274,989 (217)

Detecting Square Grid Structure in an Animal Neuronal Network

NeuroSci, 2022
An animal neural system ranges from a cluster of a few neurons to a brain of billions. At the lower range, it is possible to test each neuron for its role across a set of environmental conditions. However, the higher range requires another approach.
Robert Friedman
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cu₁₄H₁₂(P^tBu₃)₆Cl₂—The Expanse of Stryker’s Reagent

Molecules
Although a large number of copper hydride complexes and clusters have been reported, phosphine-stabilized copper hydrides remain comparatively rare. This is particularly noteworthy given the continuing interest in Stryker’s reagent [HCu(PPh3)]6 due to ...
Markus Strienz, Roman Kimmich, Alexander Conzelmann, Andreas Schnepf   +3 more
doaj   +1 more source

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Cells, 2021
Neuronal culture was used to investigate neuronal function in physiological and pathological conditions. Despite its inevitability, primary neuronal culture remained a gold standard method that requires laborious preparation, intensive training, and ...
Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks

Frontiers in Cellular Neuroscience, 2017
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated.
Peter Verstraelen, Jan R. Detrez, Marlies Verschuuren, Jacobine Kuijlaars, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos, Winnok H. De Vos   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Schizophrenia-Mimicking Layers Outperform Conventional Neural Network Layers

Frontiers in Neurorobotics, 2022
We have reported nanometer-scale three-dimensional studies of brain networks of schizophrenia cases and found that their neurites are thin and tortuous when compared to healthy controls.
Ryuta Mizutani, Senta Noguchi, Rino Saiga, Yuichi Yamashita, Mitsuhiro Miyashita, Makoto Arai, Masanari Itokawa, Masanari Itokawa   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source