Results 31 to 40 of about 276,634 (267)

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Fluorescence microscopy shadow imaging for neuroscience

Frontiers in Cellular Neuroscience
Fluorescence microscopy remains one of the single most widely applied experimental approaches in neuroscience and beyond and is continuously evolving to make it easier and more versatile.
V. V. G. Krishna Inavalli, Virginia Puente Muñoz, Virginia Puente Muñoz, Jonathan E. Draffin, Jonathan E. Draffin, Jan Tønnesen, Jan Tønnesen, Jan Tønnesen, Jan Tønnesen   +8 more
doaj   +1 more source

Representation and Learning in Neuronal Networks: A Conceptual Nervous System Approach

Rambam Maimonides Medical Journal, 2011
The work presented in this review describes the use of large cortical networks developing ex vivo, in a culture dish, to study principles underlying synchronization, adaptation, learning, and representation in neuronal assemblies. The motivation to study
Danny Eytan
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network

Frontiers in Cellular Neuroscience, 2018
Selective pressure may drive neural systems to process as much information as possible with the lowest energy cost. Recent experiment evidence revealed that the ratio between synaptic excitation and inhibition (E/I) in local cortex is generally ...
Lianchun Yu, Lianchun Yu, Zhou Shen, Chen Wang, Yuguo Yu   +4 more
doaj   +1 more source

Detecting Square Grid Structure in an Animal Neuronal Network

NeuroSci, 2022
An animal neural system ranges from a cluster of a few neurons to a brain of billions. At the lower range, it is possible to test each neuron for its role across a set of environmental conditions. However, the higher range requires another approach.
Robert Friedman
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cu₁₄H₁₂(P^tBu₃)₆Cl₂—The Expanse of Stryker’s Reagent

Molecules
Although a large number of copper hydride complexes and clusters have been reported, phosphine-stabilized copper hydrides remain comparatively rare. This is particularly noteworthy given the continuing interest in Stryker’s reagent [HCu(PPh3)]6 due to ...
Markus Strienz, Roman Kimmich, Alexander Conzelmann, Andreas Schnepf   +3 more
doaj   +1 more source

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Cells, 2021
Neuronal culture was used to investigate neuronal function in physiological and pathological conditions. Despite its inevitability, primary neuronal culture remained a gold standard method that requires laborious preparation, intensive training, and ...
Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source