Results 111 to 120 of about 841,514 (309)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Homeostatic plasticity improves signal propagation in continuous time recurrent neural networks

, 2005
Continuous-time recurrent neural networks (CTRNNs) are potentially an excellent substrate for the generation of adaptive behaviour in artificial autonomous agents. However, node saturation effects in these networks can leave them insensitive to input and
Williams, Hywel, Noble, Jason
core   +1 more source

INHIBITION OF MICROGLIA IN A ANIMAL MODEL OF SELECTIVE NEURODEGENERATION, THE PURKINJE CELL DEGENERATION MUTANT MOUSE

IBRO Neuroscience Reports, 2023
David Pérez-Boyero, Pablo González Téllez De Meneses, Ingrid Reverte Soler, Davide Ragozzino, Eduardo Weruaga Prieto, David Díaz López   +5 more
doaj   +1 more source

Analog Classification of Human Hand Gestures Exploiting Dendritic Integration With an Organic Artificial Soma

Advanced Functional Materials, EarlyView.
An organic neuromorphic architecture for the classification of human motor behavior is presented and validated. It performs somatic integration by linearly combining the activity from three muscles. An investigation of synaptic weights is presented and discussed in relationship with the classification performance.
Ilenia Sergi, Federico Rondelli, Francesco Torricelli, Federica Velluto, Anna De Salvo, Michele Di Lauro, Luciano Fadiga, Fabio Biscarini   +7 more
wiley   +1 more source

Mitochondrial plasticity: An emergent concept in neuronal plasticity and memory

International audienceMitochondria are classically viewed as 'on demand' energy suppliers to neurons in support of their activity. In order to adapt to a wide range of demands, mitochondria need to be highly dynamic and capable of adjusting their ...
Preat, Thomas, Pavlowsky, Alice, Plaçais, Pierre-Yves, Comyn, Typhaine   +3 more
core   +1 more source

Branch-specific plasticity enables self-organization of nonlinear computation in single neurons [PDF]

, 2011
It has been conjectured that nonlinear processing in dendritic branches endows individual neurons with the capability to perform complex computational operations that are needed in order to solve for example the binding problem.
Maass, Wolfgang, Legenstein, Robert
core   +1 more source

Neuron–glia metabolic coupling and plasticity [PDF]

Journal of Experimental Biology, 2006
SUMMARY The coupling between synaptic activity and glucose utilization(neurometabolic coupling) is a central physiological principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography (PET).
openaire   +9 more sources

Degradable, Skin‐Conformal Nanocomposite‐Based Bioelectronic Patches for High‐Fidelity Electrophysiology and Gesture‐Controlled Robotics

Advanced Functional Materials, EarlyView.
A degradable, skin‐conformal bioelectronic patch combines a starch‐dominated nanocomposite conductor with a gelatin substrate to enable sensitive strain sensing, high‐fidelity electrocardiography, electromyography, electrooculography, and machine‐learning‐assisted gesture control.
Ming Dong, Hongna Yuan, Shubo Liu, Abdulkadir Sanli, Emiliano Bilotti, Han Zhang, Pietro Cataldi, Karin Hing, Oliver Fenwick, Colin J. Humphreys, Dimitrios G. Papageorgiou   +10 more
wiley   +1 more source

Neuronal Activity Causes Rapid Changes of Lateral Amygdala Neuronal Membrane Properties and Reduction of Synaptic Integration and Synaptic PlasticityIn Vivo

, 2011
Neuronal membrane properties dictate neuronal responsiveness. Plasticity of membrane properties alters neuronal function and can arise in response to robust neuronal activity.
J. Amiel Rosenkranz
core   +1 more source

Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation

Nature Communications
After spinal cord injury (SCI), cyclic adenosine monophosphate (cAMP) levels drop in the spinal cord, cortex and brainstem, unlike in regenerating peripheral neurons.
Beatriz Martínez-Rojas, Samuel Martín-Pérez, Esther Giraldo, Eric Lopez-Mocholi, Ana Alastrue, Yuniesky Andrade-Talavera, Jose Prius-Mengual, Guillem Paniagua, Maria Pedraza, Sonia Hingorani, Benjamin R. Rost, Dietmar Schmitz, Marta Llansola, Vicente Felipo, Antonio Rodríguez-Moreno, Victoria Moreno-Manzano   +15 more
doaj   +1 more source