Results 91 to 100 of about 1,654,724 (346)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Plasticity in mammalian somatosensory cerebellar maps [PDF]

, 1996
The organization of sensory maps in mammalian brains can change following peripheral injury or experience. Such plasticity has been demonstrated for somatotopic somatosensory maps in various cortical and subcortical areas. In contrast to somatotopic maps,
Morissette, Josee
core   +1 more source

Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior

Frontiers in Neural Circuits, 2018
Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli.
Rafael C. Almada, Rafael C. Almada, Rafael C. Almada, Andreas J. Genewsky, Daniel E. Heinz, Daniel E. Heinz, Paul M. Kaplick, Norberto C. Coimbra, Norberto C. Coimbra, Norberto C. Coimbra, Carsten T. Wotjak   +10 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Connectivity reflects coding: A model of voltage-based spike-timing-dependent-plasticity with homeostasis [PDF]

, 2009
Electrophysiological connectivity patterns in cortex often show a few strong connections in a sea of weak connections. In some brain areas a large fraction of strong connections are bidirectional, in others they are mainly unidirectional.
Claudia Clopath, Lars Büsing, Wulfram Gerstner, Eleni Vasilaki   +3 more
core  

Resting state network changes induced by experimental inaudible infrasound exposure and associations with self-reported noise sensitivity and annoyance

Scientific Reports
The effects of prolonged infrasound (IS) exposure on brain function and behavior are largely unknown, with only one prior study investigating functional connectivity (FC) changes.
Caroline Garcia Forlim, Leonie Ascone, Christian Koch, Simone Kühn   +3 more
doaj   +1 more source

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

eLife, 2018
Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood.
Matthew C. W. Oswald, Paul Brooks, Maarten F. Zwart, A. Mukherjee, Ryan J H West, Carlo N. G. Giachello, Khomgrit Morarach, R. Baines, S. Sweeney, Matthias Landgraf   +9 more
semanticscholar   +1 more source

Neuronal Plasticity in the Entorhinal Cortex

Neural Plasticity, 2008
The entorhinal cortex (EC) is a unique and fascinating structure, constituting a highly parallel interface between phylogenetically old cortex (hippocampus) and higher neocortical areas. The literature related to the EC has increased dramatically in the past 30 years. A simple PubMed search for EC lists around 20–40 articles per year in the early 1980s.
C. Andrew Chapman, Roland S. G. Jones, Min Jung   +2 more
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source