Results 81 to 90 of about 211,725 (313)

Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex

, 2004
Recent experimental work in animals has emphasized the importance of homeostatic plasticity as a means of stabilizing the properties of neuronal circuits. Here, we report a phenomenon that indicates a homeostatic pattern of cortical plasticity in healthy
Siebner, H.R., Siebner, Hartwig Roman, Lemon, Roger N., Nitsche, M.A., Paulus, Walter J., Rothwell, John C., Lemon, R.N., Nitsche, M. A., Lang, N., Paulus, W., Rizzo, V., Rothwell, J.C.   +11 more
core   +1 more source

Neuronal Plasticity in the Entorhinal Cortex

Neural Plasticity, 2008
The entorhinal cortex (EC) is a unique and fascinating structure, constituting a highly parallel interface between phylogenetically old cortex (hippocampus) and higher neocortical areas. The literature related to the EC has increased dramatically in the past 30 years. A simple PubMed search for EC lists around 20–40 articles per year in the early 1980s.
C. Andrew Chapman, Roland S. G. Jones, Min Jung   +2 more
openaire   +3 more sources

Astrocyte and Neuronal Plasticity in the Somatosensory System [PDF]

Neural Plasticity, 2015
Changing the whisker complement on a rodent’s snout can lead to two forms of experience-dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are somatotopically represented. One form, termed coding plasticity, concerns changes in synaptic transmission and connectivity between neurons.
Sims, Robert, Butcher, John B, Parri, H Rheinallt, Glazewski, Stanislaw   +3 more
openaire   +5 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels

Neural Plasticity, 2021
Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death.
Robert M. Dietz, James E. Orfila, Nicholas Chalmers, Crystal Minjarez, Jose Vigil, Guying Deng, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Phosphorylation of the actin binding protein Drebrin at S647 and is regulated by neuronal activity and PTEN

, 2013
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin ...
Rita Hendricusdottir, Louise Kay, Harwood, Adrian, Ismini E Papageorgiou, Britta J Eickholt, Harwood, Adrian John, Leslie, Nicholas R; id_orcid, van Diepen, Michael, Leslie, Nicholas R, Parsons, Madeline; id_orcid, Kreis, Patricia, Leslie, Nicholas R., Nicholas R Leslie, Kann, Oliver, Michiel van Diepen, Papageorgiou, Ismini E, Adrian Harwood, Patricia Kreis, Parsons, Maddy, Till Mack, Fox, Michael A., Kay, Louise, van Diepen, Michiel, Oliver Kann, Mack, Till, Papageorgiou, Ismini E., Hendricusdottir, Rita, Maddy Parsons, Ryves, Jonny, Jonny Ryves, Eickholt, Britta J., Eickholt, Britta J   +31 more
core   +1 more source

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

eLife, 2017
The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecular ...
Paula A Pousinha, Xavier Mouska, Elisabeth F Raymond, Carole Gwizdek, Gihen Dhib, Gwenola Poupon, Laure-Emmanuelle Zaragosi, Camilla Giudici, Ingrid Bethus, Emilie Pacary, Michael Willem, Hélène Marie   +11 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source