Results 61 to 70 of about 841,514 (309)

Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior

Frontiers in Neural Circuits, 2018
Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli.
Rafael C. Almada, Rafael C. Almada, Rafael C. Almada, Andreas J. Genewsky, Daniel E. Heinz, Daniel E. Heinz, Paul M. Kaplick, Norberto C. Coimbra, Norberto C. Coimbra, Norberto C. Coimbra, Carsten T. Wotjak   +10 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

GluA4 Dependent Plasticity Mechanisms Contribute to Developmental Synchronization of the CA3-CA1 Circuitry in the Hippocampus [PDF]

, 2017
During the course of development, molecular mechanisms underlying activity-dependent synaptic plasticity change considerably. At immature CA3-CA1 synapses in the hippocampus, PKA-driven synaptic insertion of GluA4 AMPA receptors is the predominant ...
Lauri, Sari Elina, Atanasova, Tsvetomira, Taira, Tomi Petteri, Luchkina, Natalia, Kharybina, Zoya, Kaarela, Tiina Anna Marjatta, Huupponen, Johanna Tuulia, Tiina Kaarela, Sari E. Lauri, Johanna Huupponen, Natalia V. Luchkina, Zoya Kharybina, Tsvetomira Atanasova, Tomi Taira   +13 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Reinforcement learning in populations of spiking neurons [PDF]

, 2008
Population coding is widely regarded as a key mechanism for achieving reliable behavioral responses in the face of neuronal variability. But in standard reinforcement learning a flip-side becomes apparent.
Urbanczik, R, Walter Senn, Robert Urbanczik, Senn, W, Urbanczik R, Urbanczik, Robert, Senn W   +6 more
core   +1 more source

Bone Marrow Contributes Simultaneously to Different Neural Types in the Central Nervous System through Different Mechanisms of Plasticity

Cell Transplantation, 2011
Many studies have reported the contribution of bone marrow-derived cells (BMDC) to the CNS, raising the possibility of using them as a new source to repair damaged brain tissue or restore neuronal function.
Javier S. Recio, Manuel Álvarez-Dolado, David Díaz, Fernando C. Baltanás, Marina Piquer-Gil, José R. Alonso, Eduardo Weruaga Ph.D.   +6 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli

Translational Psychiatry
The ability to differentiate between rewarding and aversive stimuli is crucial for survival, yet the underlying neural mechanisms allowing animals to make such a distinction remain elusive. Here, using in vivo two-photon calcium imaging, we uncovered how
Łukasz Bijoch, Justyna Wiśniewska, Paweł Szczypkowski, Monika Pawłowska, Karolina Hajdukiewicz, Radek Lapkiewicz, Anna Beroun   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Diet and cognition: interplay between cell metabolism and neuronal plasticity. [PDF]

, 2013
Purpose of studyTo discuss studies in humans and animals revealing the ability of foods to benefit the brain: new information with regards to mechanisms of action and the treatment of neurological and psychiatric disorders.Recent findingsDietary factors ...
Gomez-Pinilla, Fernando, Tyagi, Ethika
core   +1 more source