Results 51 to 60 of about 211,725 (313)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Protects Striatal Cells and Improves Motor Function in Huntington’s Disease Models: Role of PAC1 Receptor

open access: yesFrontiers in Pharmacology, 2022
Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the expression of mutant huntingtin (mHtt). One of the main features of HD is the degeneration of the striatum that leads to motor discoordination. Pituitary adenylate cyclase-
Irene Solés-Tarrés   +11 more
doaj   +1 more source

The maternal brain: an organ with peripartal plasticity. [PDF]

open access: yes, 2014
The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been ...
Aigner, Ludwig   +7 more
core   +1 more source

Social maintenance masks induced aggression in zebrafish

open access: yesScientific Reports
Animal behavior is dynamically shaped by internal states and external social contexts. This study examines how internal states and social buffering influence aggression and social behavior.
Ashil Arroth Kuniyil   +7 more
doaj   +1 more source

Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients

open access: yesBiomedicines, 2021
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability worldwide without any validated biomarker or set of biomarkers to help the diagnosis and evaluation of the evolution/prognosis of TBI patients.
Víctor Farré-Alins   +20 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Foldscope as an Innovative Teaching Tool

open access: yesEducation Sciences, 2022
This study deals with the descriptive analysis of the opinion of a pilot group of students at the University of Salamanca about the use of an innovative origami microscope: the Foldscope.
Carlos Hernández-Pérez   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Independent component analysis in spiking neurons

open access: yes, 2010
Although models based on independent component analysis (ICA) have been successful in explaining various properties of sensory coding in the cortex, it remains unclear how networks of spiking neurons using realistic plasticity rules can realize such ...
Cristina Savin   +8 more
core   +1 more source

Plasticity in mammalian somatosensory cerebellar maps [PDF]

open access: yes, 1996
The organization of sensory maps in mammalian brains can change following peripheral injury or experience. Such plasticity has been demonstrated for somatotopic somatosensory maps in various cortical and subcortical areas. In contrast to somatotopic maps,
Morissette, Josee
core   +1 more source

Relevance of Cognition and Emotion for Patient-Reported Quality of Life After Stroke in Working Age: An Observational Cohort Study

open access: yesFrontiers in Neurology, 2022
BackgroundPatient-reported quality of life (QoL) may help to capture sequela of stroke more comprehensively. We aimed to investigate QoL in working age persons with ischemic stroke regarding impaired domains and identify factors associated with better ...
Daniela Pinter   +15 more
doaj   +1 more source

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