Results 91 to 100 of about 127,268 (310)

Optogenetic perturbations reveal the dynamics of an oculomotor integrator [PDF]

, 2014
Many neural systems can store short-term information in persistently firing neurons. Such persistent activity is believed to be maintained by recurrent feedback among neurons.
Arrenberg, AB, Baier, H, Gonçalves, PJ, Hablitzel, B, Machens, CK   +4 more
core   +2 more sources

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Correlation with basic differentiation processes of neurons [PDF]

, 1991
The development of the spinal cord involves the proliferation of neurons, their migration to well-defined areas, fiber outgrowth and synapse formation. The present study was designed to correlate the spatiotemporal pattern of expression of synaptophysin,
Altman, Angulo, Bööj, Cabalka, Chun, Dennis, Devoto, Hsu, Jahn, Jahn, Jahn, Kanemitsu, Kaplan, Knaus, Leclerc, Leube, Ley, Lizardi, Lupa, Mandler, Narayanan, Nornes, Nornes, Oppenheim, Phelps, Ritchie, Ruppert, Saito, Sarthy, Schilling, Stein, Südhof, Thomas, Vaughn, Vaughn, Vaughn, Vaughn, Xue   +37 more
core   +2 more sources

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, EarlyView.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology
It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons.
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
doaj   +1 more source

Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

Nature Communications, 2016
Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature
Cristina V. Dieni, Roberto Panichi, James B. Aimone, Chay T. Kuo, Jacques I. Wadiche, Linda Overstreet-Wadiche   +5 more
doaj   +1 more source

A Large‐Area Broadband Multimodal Dual‐Resonant Haptic Device for Bidirectional Telerobotic and Augmented Interactions

Advanced Science, EarlyView.
We present a large‐area bidirectional human–machine interface integrating electrostatic multimodal tactile sensing with a dual‐resonant haptic actuator. The system enables linear pressure sensing that is decoupled from actuation and stable broadband vibrotactile feedback under dynamic contact conditions, supporting real‐time feedback modulation aligned
Jihun Son, Joon Hyeok Kang, Jaeha Park, Yoon‐Gi Ku, Yongjun Lee, Jinhyung Kim, Minjin Kim, Jun Hyeok Lee, Junsik Shin, Minwoo Song, Gui Won Hwang, Dongbum Pyo, Gwanghyun Jo, Jeong‐Hoi Koo, Young‐Min Kim, Changhyun Pang, Tae‐Heon Yang   +16 more
wiley   +1 more source

Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse.

PLoS ONE, 2019
The normal function of the mammalian reproductive axis is strongly influenced by physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded by the Kiss1 gene, are potent regulators of the mammalian reproductive axis by ...
Shel-Hwa Yeo, Victoria Kyle, Clemence Blouet, Susan Jones, William Henry Colledge   +4 more
doaj   +1 more source

Characterisation of the primary afferent spinal innervation of mouse uterus

Frontiers in Neuroscience, 2014
The primary afferent innervation of the uterus is incompletely understood. The aim of this study was to identify the location and characteristics of primary afferent neurons that innervate the uterine horn of mice and correlate the different ...
Geraldine eHerweijer, Melinda eKyloh, Elizabeth A H Beckett, Kelsi eDodds, Nick J Spencer   +4 more
doaj   +1 more source

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source