Ultraviolet-B sensitizes silent nociceptors and desensitizes C-touch fibers to slow depolarizing electrical stimuli in pigs [PDF]
PAIN Reports. Introduction:. Tetrodotoxin-resistant voltage-sensitive sodium channel subtypes 1.8 and 1.9 play a key role on “silent” (mechano-insensitive) nociceptors activation during sinusoidal electrical stimulation.
Sabrina Soares +2 more
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Central role for fast nociceptors in mechanical nocifensive behavior and sensitization [PDF]
Nature CommunicationsNociceptors, primary afferent nerve fibers that signal noxious stimuli, are broadly divided into slowly conducting unmyelinated C fibers and fast-conducting myelinated A fibers.
John Chwen-Yu Chen +14 more
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TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors [PDF]
Frontiers in Cellular Neuroscience, 2020 Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r ...
Robin Jonas +10 more
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Targeting Gi/o-coupled GPCRs to inhibit nociceptors: Insights from the serotonin receptor Htr1b and triptans [PDF]
Cell Reports MedicineSummary: Pain perception is initiated upon activation of nociceptors of the dorsal root ganglia (DRG) and trigeminal ganglia. We identify G-protein-coupled receptors (GPCRs) expressed in CGRP+ mouse and human DRG neurons and find that agonists of several
Jing Peng +11 more
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Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
Cell Reports, 2021 Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A Landy, Chen Liu, Helen C. Lai
exaly +3 more sources
Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
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Life, 2022 In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recovery.
Larisa Ryskalin +4 more
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Pathophysiology, 2022 Pain and nociception are different phenomena. Nociception is the result of complex activity in sensory pathways. On the other hand, pain is the effect of interactions between nociceptive processes, and cognition, emotions, as well as the social context ...
Marco Cascella +6 more
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Cellular and Molecular Mechanisms Underlying Pain Chronicity
Cells, 2023 Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
Manuela Simonetti, Daniela Mauceri
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Pain perception in schizophrenia: A neglected phenomenon with a great impact
European Psychiatry, 2021 Introduction A decrease in pain sensitivity has been observed in patients with schizophrenia since the beginning of the twentieth century. This hypothesis further emerged during the last decades due to many clinical findings. Objectives To study pain
N. Faouel +4 more
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