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BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]
PLoS Genetics, 2018 A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
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Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain [PDF]
Molecular Pain, 2010 Background The cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron ...
Arber Silvia +5 more
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Pain perception in schizophrenia: A neglected phenomenon with a great impact
European Psychiatry, 2021 Introduction A decrease in pain sensitivity has been observed in patients with schizophrenia since the beginning of the twentieth century. This hypothesis further emerged during the last decades due to many clinical findings. Objectives To study pain
N. Faouel +4 more
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Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
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TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors
Frontiers in Cellular Neuroscience, 2020 Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r ...
Robin Jonas +10 more
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Life, 2022 In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recovery.
Larisa Ryskalin +4 more
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Pathophysiology, 2022 Pain and nociception are different phenomena. Nociception is the result of complex activity in sensory pathways. On the other hand, pain is the effect of interactions between nociceptive processes, and cognition, emotions, as well as the social context ...
Marco Cascella +6 more
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GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception
Frontiers in Pharmacology, 2020 C. elegans PVD neurons are conserved for morphology, function and molecular determinants with mammalian polymodal nociceptors. Functions of polymodal nociceptors require activities of multiple ion channels and receptors including members of the TRP ...
Emiliano Cohen +4 more
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Cellular and Molecular Mechanisms Underlying Pain Chronicity
Cells, 2023 Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
Manuela Simonetti, Daniela Mauceri
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Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli
Frontiers in Molecular Neuroscience, 2022 Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are necessary for transmitting pain and itch signals. However, the molecular mechanism regulating nociceptor development remains largely unknown.
Zheng Cao +9 more
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