Results 1 to 10 of about 22,526 (252)
Control of myeloid cell functions by nociceptors
Frontiers in Immunology, 2023 The immune system has evolved to protect the host from infectious agents, parasites, and tumor growth, and to ensure the maintenance of homeostasis.
Pavel Hanc, Marie-Angele Messou
exaly +3 more sources
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
Cell Reports, 2021 Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A Landy +2 more
exaly +3 more sources
The nociceptor primary cilium. [PDF]
BrainAbstract The primary cilium, a single microtubule-based organelle protruding from the surface of cells, utilizes intraflagellar transport (IFT) to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signaling pathways identified by expression of ...
Ganter GK +5 more
europepmc +3 more sources
Pain perception in schizophrenia: A neglected phenomenon with a great impact
European Psychiatry, 2021 Introduction A decrease in pain sensitivity has been observed in patients with schizophrenia since the beginning of the twentieth century. This hypothesis further emerged during the last decades due to many clinical findings. Objectives To study pain
N. Faouel +4 more
doaj +1 more source
Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
doaj +1 more source
TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors
Frontiers in Cellular Neuroscience, 2020 Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r ...
Robin Jonas +10 more
doaj +1 more source
Life, 2022 In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recovery.
Larisa Ryskalin +4 more
doaj +1 more source
Pathophysiology, 2022 Pain and nociception are different phenomena. Nociception is the result of complex activity in sensory pathways. On the other hand, pain is the effect of interactions between nociceptive processes, and cognition, emotions, as well as the social context ...
Marco Cascella +6 more
doaj +1 more source
Cellular and Molecular Mechanisms Underlying Pain Chronicity
Cells, 2023 Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
Manuela Simonetti, Daniela Mauceri
doaj +1 more source
GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception
Frontiers in Pharmacology, 2020 C. elegans PVD neurons are conserved for morphology, function and molecular determinants with mammalian polymodal nociceptors. Functions of polymodal nociceptors require activities of multiple ion channels and receptors including members of the TRP ...
Emiliano Cohen +4 more
doaj +1 more source