Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Fang, Xin, Dr. +17 more
core +1 more source
Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors
Frontiers in Neuroscience, 2022 Acupoint is the key area for needling treatment, but its physiology is not yet understood. Nociceptors, one of the responders in acupoints, are responsible for acupuncture manipulation and delivering acupuncture signals to the spinal or supraspinal level.
Xiang Cui, Kun Liu, Xinyan Gao, Bing Zhu
doaj +1 more source
Epac and nociceptor sensitization [PDF]
Molecular Pain, 2017 Primary sensory neurons are responsible for transmitting sensory information from the peripheral to the central nervous system. Their responses to incoming stimulation become greatly enhanced and prolonged following inflammation, giving rise to exaggerated nociceptive responses and chronic pain.
Huang, Li-Yen M, Gu, Yanping
openaire +2 more sources
Adenosine-induced activation of esophageal nociceptors [PDF]
, 2011 Clinical studies implicate adenosine acting on esophageal nociceptive pathways in the pathogenesis of noncardiac chest pain originating from the esophagus. However, the effect of adenosine on esophageal afferent nerve subtypes is incompletely understood.
M. Brozmanova +3 more
core +1 more source
The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors
Frontiers in Molecular Neuroscience, 2017 Peripheral nociceptive neurons encode and convey injury-inducing stimuli toward the central nervous system. In normal conditions, tight control of nociceptive resting potential prevents their spontaneous activation.
Omer Barkai +11 more
doaj +1 more source
Nociceptors—Noxious Stimulus Detectors [PDF]
, 2007 Clinical pain is a serious public health issue. Treatment of pain-related suffering requires knowledge of how pain signals are initially interpreted and subsequently transmitted and perpetuated.
Woolf, Clifford J. +3 more
core +1 more source
Acta Scientiarum. Health Sciences, 2012 Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos +3 more
doaj +1 more source
Compound 52 reduced the ongoing spontaneous activity of C-fiber nociceptors but not Aδ-fiber nociceptors. [PDF]
, 2015 Intravenous injection of compound 52 decreased ongoing spontaneous activity of C-fiber nociceptors sensitized by intraplantar administration of CFA (upper panel).
Darryl T. Hamamoto (797166) +13 more
core +1 more source
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs):focussing on C-polymodal nociceptors, Aβ-nociceptors, moderate pressure receptors and their receptive field depths [PDF]
, 2019 A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that much lower percentages of nociceptors were polymodal-nociceptors (PMNs) (Emery et al., 2016), than the 50–80% values in many electrophysiological fiber studies.This ...
Fang, Xin +2 more
core +4 more sources