Results 21 to 30 of about 22,526 (252)
Role of TMEM100 in mechanically insensitive nociceptor un-silencing
Nature Communications, 2023 Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity.
Timo A. Nees +17 more
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Acta Scientiarum. Health Sciences, 2012 Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos +3 more
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Emulating Nociceptive Receptor and LIF Neuron Behavior via ZrOx‐based Threshold Switching Memristor
Advanced Electronic Materials, 2023 For the progress of artificial neural networks, the imitation of multiple biological functions is indispensable for processing more tasks in a complex working environment.
Jia‐He Yang +3 more
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Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations
Pharmaceuticals, 2016 Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel
Man-Kyo Chung, James N. Campbell
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γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
Frontiers in Immunology, 2021 γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance.
Yunxuan Li, Yixi Zhang, Xun Zeng
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Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]
Korean Journal of Anesthesiology, 2011 The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg +2 more
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The Pharmacology of Nociceptor Priming [PDF]
, 2015 Nociceptors and neurons in the central nervous system (CNS) that receive nociceptive input show remarkable plasticity in response to injury. This plasticity is thought to underlie the development of chronic pain states. Hence, further understanding of the molecular mechanisms driving and maintaining this plasticity has the potential to lead to novel ...
Ram, Kandasamy, Theodore J, Price
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Frontiers in Physiology, 2012 Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG).
Edgar T Walters
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Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
Frontiers in Immunology, 2021 Bidirectional interplay between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is facilitated by a variety of cytokines, inflammatory mediators and neuropeptides.
Daniel B. Lowy +2 more
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Frontiers in Pain ResearchOrthodontic forces are strongly associated with pain, the primary complaint among patients wearing orthodontic braces. Compared to other side effects of orthodontic treatment, orthodontic pain is often overlooked, with limited clinical management ...
Sheng Wang +3 more
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