Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
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Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]
, 2010 Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under normal conditions, and contribute to debilitating bladder pain and/or overactivity in pathological states. The goal of this study was to examine the respective roles
DeBerry, Jennifer J +7 more
core +4 more sources
Emulating Nociceptive Receptor and LIF Neuron Behavior via ZrOx‐based Threshold Switching Memristor
Advanced Electronic Materials, 2023 For the progress of artificial neural networks, the imitation of multiple biological functions is indispensable for processing more tasks in a complex working environment.
Jia‐He Yang +3 more
doaj +1 more source
Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. [PDF]
, 2015 This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the ...
Bautista, Diana
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Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]
, 2015 Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA +4 more
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Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations
Pharmaceuticals, 2016 Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel
Man-Kyo Chung, James N. Campbell
doaj +1 more source
γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
Frontiers in Immunology, 2021 γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance.
Yunxuan Li, Yixi Zhang, Xun Zeng
doaj +1 more source
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
core +1 more source
Frontiers in Physiology, 2012 Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG).
Edgar T Walters
doaj +1 more source
Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]
Korean Journal of Anesthesiology, 2011 The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg +2 more
doaj +1 more source