Results 21 to 30 of about 27,783 (192)
GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception
Frontiers in Pharmacology, 2020 C. elegans PVD neurons are conserved for morphology, function and molecular determinants with mammalian polymodal nociceptors. Functions of polymodal nociceptors require activities of multiple ion channels and receptors including members of the TRP ...
Emiliano Cohen +4 more
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Fang, Xin, Dr. +17 more
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Epac and nociceptor sensitization [PDF]
Molecular Pain, 2017 Primary sensory neurons are responsible for transmitting sensory information from the peripheral to the central nervous system. Their responses to incoming stimulation become greatly enhanced and prolonged following inflammation, giving rise to exaggerated nociceptive responses and chronic pain.
Huang, Li-Yen M, Gu, Yanping
openaire +2 more sources
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan +21 more
core +1 more source
Acta Scientiarum. Health Sciences, 2012 Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos +3 more
doaj +1 more source
Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors
Frontiers in Neuroscience, 2022 Acupoint is the key area for needling treatment, but its physiology is not yet understood. Nociceptors, one of the responders in acupoints, are responsible for acupuncture manipulation and delivering acupuncture signals to the spinal or supraspinal level.
Xiang Cui, Kun Liu, Xinyan Gao, Bing Zhu
doaj +1 more source
The Pharmacology of Nociceptor Priming [PDF]
, 2015 Nociceptors and neurons in the central nervous system (CNS) that receive nociceptive input show remarkable plasticity in response to injury. This plasticity is thought to underlie the development of chronic pain states. Hence, further understanding of the molecular mechanisms driving and maintaining this plasticity has the potential to lead to novel ...
Ram, Kandasamy, Theodore J, Price
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Nociceptors—Noxious Stimulus Detectors [PDF]
, 2007 Clinical pain is a serious public health issue. Treatment of pain-related suffering requires knowledge of how pain signals are initially interpreted and subsequently transmitted and perpetuated.
Woolf, Clifford J. +3 more
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Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations
Pharmaceuticals, 2016 Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel
Man-Kyo Chung, James N. Campbell
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Role of TMEM100 in mechanically insensitive nociceptor un-silencing
Nature Communications, 2023 Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity.
Timo A. Nees +17 more
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