Results 11 to 20 of about 22,526 (252)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Defining the nociceptor transcriptome [PDF]

Frontiers in Molecular Neuroscience, 2014
Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets.
Thakur, Matthew, Crow, Megan, Richards, Natalie, Davey, Gareth I J, Levine, Emma, Kelleher, Jayne H, Agley, Chibeza C, Denk, Franziska, Harridge, Stephen D R, McMahon, Stephen B   +9 more
openaire   +4 more sources

Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli

Frontiers in Molecular Neuroscience, 2022
Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are necessary for transmitting pain and itch signals. However, the molecular mechanism regulating nociceptor development remains largely unknown.
Zheng Cao, Zheng Cao, Chengcheng Huang, Chengcheng Huang, Fumin Lu, Xuequan Jiang, Xuequan Jiang, Yong Hu, Cheng Cao, Zijing Liu   +9 more
doaj   +1 more source

Inhibition of visceral nociceptors [PDF]

Frontiers in Pharmacology, 2014
Abdominal pain is one of the most frequent reasons for consulting a doctor. Despite it being a common clinical presentation, abdominal pain remains a difficult entity to treat. This is a result of multiple factors including time course (i.e., acute vs. chronic), etiology (e.g., inflammatory vs.
Reed, David E., Blackshaw, L. Ashley
openaire   +3 more sources

BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]

PLoS Genetics, 2018
A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
doaj   +1 more source

Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors

Frontiers in Neuroscience, 2022
Acupoint is the key area for needling treatment, but its physiology is not yet understood. Nociceptors, one of the responders in acupoints, are responsible for acupuncture manipulation and delivering acupuncture signals to the spinal or supraspinal level.
Xiang Cui, Kun Liu, Xinyan Gao, Bing Zhu
doaj   +1 more source

Epac and nociceptor sensitization [PDF]

Molecular Pain, 2017
Primary sensory neurons are responsible for transmitting sensory information from the peripheral to the central nervous system. Their responses to incoming stimulation become greatly enhanced and prolonged following inflammation, giving rise to exaggerated nociceptive responses and chronic pain.
Huang, Li-Yen M, Gu, Yanping
openaire   +2 more sources

The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors

Frontiers in Molecular Neuroscience, 2017
Peripheral nociceptive neurons encode and convey injury-inducing stimuli toward the central nervous system. In normal conditions, tight control of nociceptive resting potential prevents their spontaneous activation.
Omer Barkai, Omer Barkai, Robert H. Goldstein, Robert H. Goldstein, Yaki Caspi, Yaki Caspi, Ben Katz, Ben Katz, Shaya Lev, Shaya Lev, Alexander M. Binshtok, Alexander M. Binshtok   +11 more
doaj   +1 more source

Nociceptors: a phylogenetic view [PDF]

Journal of Comparative Physiology A, 2009
The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt "detect and protect" system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli ...
Smith, E.S.J., Lewin, G.R.
openaire   +2 more sources

Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors

Molecular Pain, 2018
Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors.
Irina Schaefer, Vincenzo Prato, Alice Arcourt, Francisco J Taberner, Stefan G Lechner   +4 more
doaj   +1 more source