Results 11 to 20 of about 27,783 (192)

Nociceptors: a phylogenetic view [PDF]

Journal of Comparative Physiology A, 2009
The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt "detect and protect" system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli ...
Smith, E.S.J., Lewin, G.R.
openaire   +4 more sources

BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]

PLoS Genetics, 2018
A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
doaj   +4 more sources

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors [PDF]

Cell Reports, 2017
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner   +10 more
doaj   +4 more sources

Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors [PDF]

Molecular Pain, 2018
Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors.
Irina Schaefer, Vincenzo Prato, Alice Arcourt, Francisco J Taberner, Stefan G Lechner   +4 more
doaj   +2 more sources

Nociceptors for the 21st Century

Current Review of Pain, 2000
This review summarizes recent developments in the context of the neurochemical classification of nociceptors and explores the relationships between functionally and neurochemically defined subgroups. Although the complete picture is not yet available, several lines of intriguing evidence suggest that despite the complexity and diversity of nociceptor ...
Alvarez, Francisco J., Fyffe, Robert E.W.   +1 more
openaire   +5 more sources

The nociceptor primary cilium. [PDF]

Brain
Abstract The primary cilium, a single microtubule-based organelle protruding from the surface of cells, uses intraflagellar transport to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signalling pathways identified by expression of molecular ...
Ganter GK, Reveche HC, Fitzsimons LA, Khomula EV, Levine JD, Tucker KL.   +5 more
europepmc   +3 more sources

Mechanisms regulating excitability of primary afferent nociceptors

, 2002
The perception of pain - burning, aching and soreness - acts as a physiological warning that protects us from real or potential injury by employing both behavioural and reflex avoidance responses.
Bikramjit. Chopra (7651850)
core   +6 more sources

Defining the nociceptor transcriptome [PDF]

Frontiers in Molecular Neuroscience, 2014
Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets.
Thakur, Matthew, Crow, Megan, Richards, Natalie, Davey, Gareth I J, Levine, Emma, Kelleher, Jayne H, Agley, Chibeza C, Denk, Franziska, Harridge, Stephen D R, McMahon, Stephen B   +9 more
openaire   +4 more sources

Inhibition of visceral nociceptors [PDF]

Frontiers in Pharmacology, 2014
Abdominal pain is one of the most frequent reasons for consulting a doctor. Despite it being a common clinical presentation, abdominal pain remains a difficult entity to treat. This is a result of multiple factors including time course (i.e., acute vs. chronic), etiology (e.g., inflammatory vs.
Reed, David E., Blackshaw, L. Ashley
openaire   +3 more sources

Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli

Frontiers in Molecular Neuroscience, 2022
Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are necessary for transmitting pain and itch signals. However, the molecular mechanism regulating nociceptor development remains largely unknown.
Zheng Cao, Zheng Cao, Chengcheng Huang, Chengcheng Huang, Fumin Lu, Xuequan Jiang, Xuequan Jiang, Yong Hu, Cheng Cao, Zijing Liu   +9 more
doaj   +1 more source