Results 11 to 20 of about 28,462 (324)
BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]
PLoS Genetics, 2018 A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
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Nociceptors: a phylogenetic view [PDF]
Journal of Comparative Physiology A, 2009 The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt "detect and protect" system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli ...
Smith, E.S.J., Lewin, G.R.
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Nociceptors for the 21st Century [PDF]
Current Review of Pain, 2000 This review summarizes recent developments in the context of the neurochemical classification of nociceptors and explores the relationships between functionally and neurochemically defined subgroups. Although the complete picture is not yet available, several lines of intriguing evidence suggest that despite the complexity and diversity of nociceptor ...
Alvarez, Francisco J. +1 more
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Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors [PDF]
Cell Reports, 2017 Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato +10 more
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Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors [PDF]
Molecular Pain, 2018 Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors.
Irina Schaefer +4 more
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The nociceptor primary cilium. [PDF]
BrainAbstract The primary cilium, a single microtubule-based organelle protruding from the surface of cells, uses intraflagellar transport to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signalling pathways identified by expression of molecular ...
Ganter GK +5 more
europepmc +3 more sources
Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultra‐violet irradiation. [PDF]
, 1987 1. The activity of single C- and A-fibre cutaneous sensory units was recorded from the great auricular nerve of anaesthetized rabbits to compare the effects of chemical with other forms of stimulation under several experimental conditions.
Janós Szolcsányi
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Defining the nociceptor transcriptome [PDF]
Frontiers in Molecular Neuroscience, 2014 Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets.
Thakur, Matthew +9 more
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Inhibition of visceral nociceptors [PDF]
Frontiers in Pharmacology, 2014 Abdominal pain is one of the most frequent reasons for consulting a doctor. Despite it being a common clinical presentation, abdominal pain remains a difficult entity to treat. This is a result of multiple factors including time course (i.e., acute vs. chronic), etiology (e.g., inflammatory vs.
Reed, David E., Blackshaw, L. Ashley
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