Results 31 to 40 of about 22,526 (252)
Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors
Cell Reports, 2017 Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato +10 more
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SmartMat, 2023 Artificial synapses and neurons are crucial milestones for neuromorphic computing hardware, and memristors with resistive and threshold switching characteristics are regarded as the most promising candidates for the construction of hardware neural ...
Fu‐Dong Wang +11 more
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Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
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Molecular Mechanisms That Contribute to Bone Marrow Pain
Frontiers in Neurology, 2017 Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the ...
Jason J. Ivanusic
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Advanced Science, 2022 A biological receptor serves as sensory transduction from an external stimulus to an electrical signal. It allows humans to better match the environment by filtering out repetitive innocuous information and recognize potentially damaging stimuli through ...
Young Geun Song +10 more
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Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application
Advanced Materials, EarlyView.This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong +12 more
wiley +1 more source
ToxinsCurrently, commercially available pain medications can cause adverse effects. Within this framework, researchers have been exploring new drug candidates derived from animal venoms and toxins.
Davi Gomes Angstmam +6 more
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Molecular Pain, 2014 Background: Tissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown.
Wei-Nan Chen +6 more
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Skin‐Like Tri‐Modal Sensors Based on Soft Piezoelectric and Ionic Composites
Advanced Materials Technologies, EarlyView.Inspired by the multimodal perception of human skin, a soft, skin‐like tri‐modal sensor is presented. The device incorporates an ionically conductive, piezoelectric, elastic composite as its active layer, enabling independent detection of temperature, static strain, and dynamic strain within a single two‐terminal architecture.
Liren Wang +9 more
wiley +1 more source
Frontiers in Molecular BiosciencesThis review delves into the intricate biological underpinnings of pain perception. It encompasses nociceptive signaling pathways, the molecular mechanisms involved, and the subjective experience of discomfort in humans. The initial focus is on nociceptor
Bahar Dehghan +3 more
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