Results 31 to 40 of about 39,802 (268)
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
Frontiers in Immunology, 2021 Bidirectional interplay between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is facilitated by a variety of cytokines, inflammatory mediators and neuropeptides.
Daniel B. Lowy +2 more
doaj +1 more source
Frontiers in Pain ResearchOrthodontic forces are strongly associated with pain, the primary complaint among patients wearing orthodontic braces. Compared to other side effects of orthodontic treatment, orthodontic pain is often overlooked, with limited clinical management ...
Sheng Wang +3 more
doaj +1 more source
Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors
Cell Reports, 2017 Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato +10 more
doaj +1 more source
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
Cell Reports, 2021 Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A. Landy +4 more
doaj +1 more source
The pain matrix reloaded: a salience detection system for the body [PDF]
, 2011 Neuroimaging and neurophysiological studies have shown that nociceptive stimuli elia salience detection system for the bodycit responses in an extensive cortical network including somatosensory, insular and cingulate areas, as well as frontal and ...
Iannetti, Gian Domenico +3 more
core +2 more sources
Nociceptor neurons promote IgE class switch in B cells
JCI Insight, 2021 Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in the periphery to modulate innate immune responses. Whether they also participate in adaptive and humoral immunity is, however, not known.
Shreya Mathur +10 more
doaj +1 more source
SmartMat, 2023 Artificial synapses and neurons are crucial milestones for neuromorphic computing hardware, and memristors with resistive and threshold switching characteristics are regarded as the most promising candidates for the construction of hardware neural ...
Fu‐Dong Wang +11 more
doaj +1 more source
Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
doaj +1 more source
Molecular Mechanisms That Contribute to Bone Marrow Pain
Frontiers in Neurology, 2017 Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the ...
Jason J. Ivanusic
doaj +1 more source