Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan +21 more
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High spontaneous activity of C-nociceptors in painful polyneuropathy [PDF]
, 2012 Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes.
Orstavik, Kristin +7 more
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HMGB1 released from nociceptors mediates inflammation. [PDF]
, 2021 Inflammation, the body's primary defensive response system to injury and infection, is triggered by molecular signatures of microbes and tissue injury. These molecules also stimulate specialized sensory neurons, termed nociceptors.
Gunasekaran, Manojkumar +17 more
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Emulating Nociceptive Receptor and LIF Neuron Behavior via ZrOx‐based Threshold Switching Memristor
Advanced Electronic Materials, 2023 For the progress of artificial neural networks, the imitation of multiple biological functions is indispensable for processing more tasks in a complex working environment.
Jia‐He Yang +3 more
doaj +1 more source
Compound 52 attenuated CFA-induced sensitization of C-fiber nociceptors but not Aδ-fiber nociceptors to mechanical stimuli. [PDF]
, 2015 A, Mechanical response thresholds of sensitized C-fiber nociceptors increased at 30 minutes (p = 0.07) and 60 minutes (p < 0.001) following intravenous injection of compound 52.
Darryl T. Hamamoto (797166) +13 more
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Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations
Pharmaceuticals, 2016 Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel
Man-Kyo Chung, James N. Campbell
doaj +1 more source
γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
Frontiers in Immunology, 2021 γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance.
Yunxuan Li, Yixi Zhang, Xun Zeng
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The Pharmacology of Nociceptor Priming [PDF]
, 2015 Nociceptors and neurons in the central nervous system (CNS) that receive nociceptive input show remarkable plasticity in response to injury. This plasticity is thought to underlie the development of chronic pain states. Hence, further understanding of the molecular mechanisms driving and maintaining this plasticity has the potential to lead to novel ...
Ram, Kandasamy, Theodore J, Price
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Mechanical response properties of nociceptors innervating feline hairy skin [PDF]
, 1996 1. The responses of feline cutaneous nociceptors were examined in vivo by systematically manipulating the intensive and spatial dimensions of mechanical stimulation.
J. D. Greenspan +2 more
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Frontiers in Physiology, 2012 Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG).
Edgar T Walters
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