Results 51 to 60 of about 27,783 (192)

High spontaneous activity of C-nociceptors in painful polyneuropathy

, 2012
Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes.
Orstavik, Kristin, Helas, Tormod, Kleggetveit, Inge Petter, Schmelz, Martin, Rueckel, Michael, Namer, Barbara, Schmidt, Roland,, Jorum, Ellen   +7 more
core   +1 more source

Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain

Molecular Pain, 2010
Background The cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron ...
Arber Silvia, Kramer Ina, Yang Fu-Chia, Liu Yang, Samad Omar, Ma Qiufu   +5 more
doaj   +1 more source

PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS

Научно-практическая ревматология, 2017
The relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties.
A. E. Karateev, D. E. Karateev, O. S. Davydov   +2 more
doaj   +1 more source

Compound 52 reduced the ongoing spontaneous activity of C-fiber nociceptors but not Aδ-fiber nociceptors.

, 2015
Intravenous injection of compound 52 decreased ongoing spontaneous activity of C-fiber nociceptors sensitized by intraplantar administration of CFA (upper panel).
Darryl T. Hamamoto (797166), Stefan I. McDonough (625984), Carrie Morgan (797172), Donald A. Simone (797174), Xingwen Li (797170), Melanie Cooke (797167), Erin F. DiMauro (797168), Jeff McDermott (797171), David J. Matson (625974), Danielle Johnson (625975), Howard Bregman (258168), Liyue Huang (797169), Ben Wilenkin (797173), Annika B. Malmberg (625983)   +13 more
core   +1 more source

Contextualized pain management in newborns

Journal of Pediatric and Neonatal Individualized Medicine, 2016
Neonatal pain treatment requires personalization, and pain assessment should be contextualized to be effective. Here we summarize the available tools in neonatal analgesia, paying a special attention to highlight the personalization of antalgic behavior,
Carlo Valerio Bellieni, Monica Tei, Giuseppe Buonocore   +2 more
doaj   +1 more source

Compound 52 attenuated CFA-induced sensitization of C-fiber nociceptors but not Aδ-fiber nociceptors to mechanical stimuli.

, 2015
A, Mechanical response thresholds of sensitized C-fiber nociceptors increased at 30 minutes (p = 0.07) and 60 minutes (p < 0.001) following intravenous injection of compound 52.
Darryl T. Hamamoto (797166), Stefan I. McDonough (625984), Carrie Morgan (797172), Donald A. Simone (797174), Xingwen Li (797170), Melanie Cooke (797167), Erin F. DiMauro (797168), Jeff McDermott (797171), David J. Matson (625974), Danielle Johnson (625975), Howard Bregman (258168), Liyue Huang (797169), Ben Wilenkin (797173), Annika B. Malmberg (625983)   +13 more
core   +1 more source

Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins

Toxins
Currently, commercially available pain medications can cause adverse effects. Within this framework, researchers have been exploring new drug candidates derived from animal venoms and toxins.
Davi Gomes Angstmam, Bruna Cristina Jeronimo, Joeliton dos Santos Cavalcante, Ana Flávia Marques Pereira, Cristiane Flora Villarreal, Daniel Carvalho Pimenta, Rui Seabra Ferreira Junior   +6 more
doaj   +1 more source

Mechanical response properties of nociceptors innervating feline hairy skin

, 1996
1. The responses of feline cutaneous nociceptors were examined in vivo by systematically manipulating the intensive and spatial dimensions of mechanical stimulation.
J. D. Greenspan, P. C. Garell, S. L. McGillis   +2 more
core   +1 more source

Non-peptidergic small diameter primary afferents expressing VGluT2 project to lamina I of mouse spinal dorsal horn

Molecular Pain, 2011
Background Unmyelinated primary afferent nociceptors are commonly classified into two main functional types: those expressing neuropeptides, and non-peptidergic fibers that bind the lectin IB4.
Clarke Jennifer N, Anderson Rebecca L, Haberberger Rainer V, Gibbins Ian L   +3 more
doaj   +1 more source

Pain threshold assessment in relation to neural mobilization therapy = Avaliação do limiar de dor frente à terapia com mobilização neural [PDF]

Acta Scientiarum. Health Sciences, 2012
Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos, Bruna Fomentão Araújo, Edson Antonio Alves da Silva, Gladson Ricardo Flor Bertolini   +3 more
doaj   +1 more source