Results 71 to 80 of about 27,783 (192)

Morphine acts in vitro to directly prime nociceptors

Molecular Pain
Hyperalgesic priming is a preclinical model of the transition from acute to chronic pain characterized by a leftward shift in the dose-response curve for and marked prolongation of prostaglandin E 2 (PGE 2 )-induced mechanical hyperalgesia, in vivo.
Eugen V. Khomula, Jon D. Levine
doaj   +1 more source

Endothelin1 activates and sensitizes human C-nociceptors

, 2007
Microneurography was used to record action potentials from afferent C-fibers in cutaneous fascicles of the peroneal nerve in healthy volunteers. Afferent fibers were classified according to their mechanical responsiveness to von Frey stimulation (75 g ...
Hilliges, Marita,, Ørstavik, Kristin, Handwerker, Hermann,, Namer, Barbara,, Schmelz, Martin, Namer, Barbara, Torebjörk, Erik,, Hilliges, Marita, Ørstavik, Kristin,, Schmelz, Martin,, Weidner, Christian,, Schmidt, Roland,, Handwerker, Hermann   +12 more
core   +1 more source

C-Fiber Assays in the Cornea vs. Skin

Brain Sciences, 2019
C-fibers are unmyelinated nerve fibers that transmit high threshold mechanical, thermal, and chemical signals that are associated with pain sensations. This review examines current literature on measuring altered peripheral nerve morphology and discusses
Eric A. Moulton, David Borsook
doaj   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

Molecular Pain, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus   +11 more
doaj   +1 more source

Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients

, 2012
Multiple firing of C nociceptors upon a single electrical stimulus has been suggested to be a possible mechanism contributing to neuropathic pain. Because this phenomenon maybe based on a unidirectional conduction block, it might also be related to ...
Helås, Tormod, Roland Schmidt, Ellen Jørum, Schmelz, Martin, Inge Petter Kleggetveit, Namer, Barbara, Jørum, Ellen, Obreja, Otilia, Tormod Helås, Otilia Obreja, Barbara Namer, Kleggetveit, Inge Petter, Martin Schmelz, Schmidt, Roland,   +13 more
core   +1 more source

Pain pathways and mechanisms of neuropathic pain

Acta Neurológica Colombiana, 2007
Several neural steps are involved in the processing of noxious signals that can lead to the experience of pain. Nociceptors readily respond to different noxious modalities such as thermal, mechanical or chemical stimuli, but nociceptors do not respond ...
Oscar A. de Leon-Casasola
doaj   +2 more sources

Recent Developments on Novel 2D Materials for Emerging Neuromorphic Computing Devices

Small Structures
The rapid advancement of artificial intelligent and information technology has led to a critical need for extremely low power consumption and excellent efficiency.
Muhammad Hamza Pervez, Ehsan Elahi, Muhammad Asghar Khan, Muhammad Nasim, Muhammad Asim, Arslan Rehmat, Malik Abdul Rehman, Mohammed A. Assiri, Shania Rehman, Jonghwa Eom, Muhammad Farooq Khan   +10 more
doaj   +1 more source

Nociceptors in antimicrobial defense [PDF]

Nature Immunology, 2020
openaire   +2 more sources

Pressing Intervention Alleviates Pain in Rats With Myofascial Trigger Points via the TRPV1 Channel in Unmyelinated C-Type Sensory Nerve Fibers

Journal of Integrative Neuroscience
Background: Although pressing intervention is widely used clinically to alleviate pain associated with chronic myofascial trigger points (MTrPs), the mechanisms by which it modulates pain via sensory nerves remain unclear.
Yuqiao Zhang, Liya Tang, Xinyue Lv, Jiangshang Li, Fei Liu, Xiaoxia Kuang, Wu Li   +6 more
doaj   +1 more source

Cutaneous inflammation alters nociceptor electrophysiology in guinea pigs but not rats

Biomolecules & Biomedicine
Inflammatory pain hypersensitivity is believed to result, in part, from increased excitability of nociceptive dorsal root ganglion (DRG) neurons. We previously demonstrated in guinea pigs that hindlimb inflammation induces electrophysiological changes ...
Laiche Djouhri , Ahmed Eliwa , Alghalya Al-Emadi , Yehia Y. Hussein , Hissa Al-Suwaidi , Al-Jouhara Albaloshi , Ayman Mustafa, Mohammed Seed Ahmed   +7 more
doaj   +1 more source