Results 61 to 70 of about 27,783 (192)
Calcineurin as a Nociceptor Modulator
Pain Physician, 2009 Calcineurin may be involved in affecting nociceptive processes in multiple circumstances. It is conceivable that interfering with calcineurin’s normal role in contributing to glial resting membrane potential, via its effects on the ion channel (TRESK) [tandem-pore-domain weakly inward rectifying potassium channels (TWIK)-related spinal cord potassium ...
openaire +2 more sources
TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors [PDF]
, 2014 SummaryPrimary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits ...
Wheeler, Michael A. +6 more
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Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury
Frontiers in Pharmacology, 2020 Clinical and preclinical studies have revealed that local administration of opioid agonists into peripheral tissue attenuates inflammatory pain. However, few studies have examined whether peripherally restricted opioids are effective in reducing ...
Marek Joukal +4 more
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Threshold Switching in Single Metal‐Oxide Nanobelt Devices Emulating an Artificial Nociceptor
Advanced Electronic Materials, 2020 Electronic devices that can simulate the dynamics of neurotransmission in the human body are of great interest for the development of artificial intelligence in modern information technology.
Ming Xiao +6 more
doaj +1 more source
A search for activation of C-nociceptors by sympathetic fibers in complex regional pain syndrome [PDF]
, 2010 Objective—Although the term ‘reflex sympathetic dystrophy’ has been replaced by ‘complex regional pain syndrome’ (CRPS) type I, there remains a widespread presumption that the sympathetic nervous system is actively involved in mediating chronic ...
Ochoa, José +3 more
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HMGB1 released from nociceptors mediates inflammation.
, 2021 Inflammation, the body's primary defensive response system to injury and infection, is triggered by molecular signatures of microbes and tissue injury. These molecules also stimulate specialized sensory neurons, termed nociceptors.
Gunasekaran, Manojkumar +17 more
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Function and Anatomy of Fast Nociceptors
Pain, a fundamental and evolutionarily conserved physiological mechanism, allows organisms to detect and avoid potential harm. In the absence of pain perception (e.g.
Chen, John Chwen-Yu
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Secondary hyperalgesia is mediated by heat-insensitive A-fibre nociceptors.
, 2016 It is believed that secondary hyperalgesia (the increased sensitivity to mechanical nociceptive stimuli that develops after cutaneous tissue injury in the surrounding uninjured skin) is mediated by a subclass of nociceptors: the slowly adapting A-fibre ...
Lenoir, Cédric +2 more
core +1 more source
, 2020 Using extracellular single‐fibre recordings from the saphenous nerve in pig in vivo, we investigated peak following frequencies (5–100 Hz) in different classes of C‐nociceptors and their modulation by nerve growth factor. Classes were defined by sensory (
Jørum, Ellen +8 more
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Responses of Cutaneous A-Fiber Nociceptors to Noxious Cold
, 1997 Simone, Donald A. and Keith C. Kajander. Responses of cutaneous A fiber nociceptors to noxious cold. J. Neurophysiol. 77: 2049–2060, 1997. Responses of cutaneous nociceptors to natural stimuli, particularly mechanical and heat stimuli, have been well ...
Keith C. Kajander, Donald A. Simone
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