Results 91 to 100 of about 2,639,581 (370)

A Review of the Role of Sphingosine-1-Phosphate in the Brain: An Important Mediator Implicated in the Central Nervous System

open access: yesWalailak Journal of Science and Technology, 2013
Sphingosine-1-phosphate (S1P) is a bioactive lipid that signals through a family of G protein-coupled receptors, consisting of 5 members, termed S1P1, S1P2, S1P3, S1P4 and S1P5.
Chuchard PUNSAWAD
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Expression of the transcription factor regulatory factor X1 in the mouse brain

open access: yesFolia Histochemica et Cytobiologica, 2011
Limited information indicates that the regulatory factor X1 (RFX1), the prototype member of the transcription factor RFX family, may play a role in the central nervous system.
Zhiyi Zuo, Jiejie Li, Chenzhuo Feng
doaj   +1 more source

Challenges in Physiological Phenotyping of hiPSC-Derived Neurons: From 2D Cultures to 3D Brain Organoids

open access: yesFrontiers in Cell and Developmental Biology, 2020
Neurons derived from human induced pluripotent stem cells (hiPSC-derived neurons) offer novel opportunities for the development of preclinical models of human neurodegenerative diseases (NDDs).
Pedro Mateos-Aparicio   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

What Is One Grain of Sand in the Desert? Analyzing Individual Neurons in Deep NLP Models

open access: yes, 2018
Despite the remarkable evolution of deep neural networks in natural language processing (NLP), their interpretability remains a challenge. Previous work largely focused on what these models learn at the representation level.
Bau, Anthony   +5 more
core   +1 more source

Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

open access: yesNeural Regeneration Research, 2015
Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu   +3 more
doaj   +1 more source

A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components

open access: yesJournal of Neuroscience, 1993
We describe a novel slow oscillation in intracellular recordings from cortical association areas 5 and 7, motor areas 4 and 6, and visual areas 17 and 18 of cats under various anesthetics.
M. Steriade, A. Nuñez, F. Amzica
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons

open access: yesApplied Sciences, 2019
Here we demonstrate that human neural stem cells (NSCs) proliferate while in space and they express specific NSC markers after being in space. NSCs displayed both higher oxygen consumption and glycolysis than ground controls.
Carlos Cepeda   +6 more
doaj   +1 more source

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