Results 111 to 120 of about 1,753,121 (371)

Effect of environmental enrichment exposure on neuronal morphology of streptozotocin-induced diabetic and stressed rat hippocampus

Biomedical Journal, 2014
Background: Environmental enrichment (EE) exposure is known to influence the structural changes in the neuronal network of hippocampus. In the present study, we evaluated the effects of EE exposure on the streptozotocin (STZ)-induced diabetic and ...
Narendra Pamidi, Satheesha Nayak
doaj   +1 more source

Bursting and Synchrony in Networks of Model Neurons [PDF]

R. Tetzlaff and C. E. Elger and K. Lehnertz (2013), Recent Advances in Predicting and Preventing Epileptic Seizures, page 108-116, Singapore, World Scientific, 2016
Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that the dynamics of neuronal networks is influenced not only by neuronal and synaptic properties but also by network ...
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Correlation and Comparison of Cortical and Hippocampal Neural Progenitor Morphology and Differentiation through the Use of Micro- and Nano-Topographies

Journal of Functional Biomaterials, 2017
Neuronal morphology and differentiation have been extensively studied on topography. The differentiation potential of neural progenitors has been shown to be influenced by brain region, developmental stage, and time in culture. However, the neurogenecity
Sharvari Sathe, Xiang Quan Chan, Jing Jin, Erik Bernitt, Hans-Günther Döbereiner, Evelyn K.F. Yim   +5 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation Of The Astrocytic Glutamate-Releasing Mechanism System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e [PDF]

, 2016
Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling.
Albano, Rebecca, Baker, David A., Choi, Sujean, Kong, Linghai, Lobner, Doug, Madayag, Aric, Mantsch, John R., Raddatz, Nicholas   +7 more
core   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Resolving the prevalence of somatic transposition in Drosophila

eLife, 2017
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline.
Christoph D Treiber, Scott Waddell
doaj   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

eLife, 2017
ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and
Veronica Musante, Lu Li, Jean Kanyo, Tukiet T Lam, Christopher M Colangelo, Shuk Kei Cheng, A Harrison Brody, Paul Greengard, Nicolas Le Novère, Angus C Nairn   +9 more
doaj   +1 more source

Microwave neural processing and broadcasting with spintronic nano-oscillators

, 2018
Can we build small neuromorphic chips capable of training deep networks with billions of parameters? This challenge requires hardware neurons and synapses with nanometric dimensions, which can be individually tuned, and densely connected.
Araujo, F. Abreu, Bortolotti, P., Cros, V., Ernoult, M., Fukushima, A., Grollier, J., Hirtzlin, T., Kubota, H., Locatelli, N., Querlioz, D., Romera, M., Talatchian, P., Trastoy, J., Tsunegi, S., Vodenicarevic, D., Yakushiji, K., Yuasa, S.   +16 more
core   +1 more source