Results 111 to 120 of about 2,597,556 (387)
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
A Leptin-regulated Circuit Controls Glucose Mobilization During Noxious Stimuli [PDF]
, 2017 Adipocytes secrete the hormone leptin to signal the sufficiency of energy stores. Reductions in circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolically ...
Allison, Margaret B. +15 more
core +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2018 Deep brain stimulation (DBS) is a widely used treatment for neurodegenerative disorders like Parkinson’s disease. Recently, several studies have used preclinical animal models to suggest that DBS has a potential to improve emotional symptoms in mental ...
Yamini Bhaskar +2 more
doaj +1 more source
Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD
Nature, 2011 Human pluripotent stem cells (PSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However,
Sonja Kriks +15 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Artificial Neurons with Arbitrarily Complex Internal Structures
, 2001 Artificial neurons with arbitrarily complex internal structure are introduced. The neurons can be described in terms of a set of internal variables, a set activation functions which describe the time evolution of these variables and a set of ...
Kohring, G. A.
core +2 more sources
Temporal Control of Axonal Transport: The Extreme Case of Organismal Ageing
Frontiers in Cellular Neuroscience, 2019 A fundamental question in cell biology is how cellular components are delivered to their destination with spatial and temporal precision within the crowded cytoplasmic environment.
Francesca Mattedi, Alessio Vagnoni
doaj +1 more source
Nature Network Boston, 2018 Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems.
Chengzhong Wang +12 more
semanticscholar +1 more source
THE FUNCTIONS OF THE NEURON [PDF]
The Journal of Nervous and Mental Disease, 1896 n ...
openaire +2 more sources