Results 91 to 100 of about 1,334,435 (305)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Synchronization in Networks of Hindmarsh-Rose Neurons [PDF]

open access: yes, 2008
Synchronization is deemed to play an important role in information processing in many neuronal systems. In this work, using a well known technique due to Pecora and Carroll, we investigate the existence of a synchronous state and the bifurcation diagram ...
Kocarev, L.   +4 more
core   +1 more source

Expression of the transcription factor regulatory factor X1 in the mouse brain

open access: yesFolia Histochemica et Cytobiologica, 2011
Limited information indicates that the regulatory factor X1 (RFX1), the prototype member of the transcription factor RFX family, may play a role in the central nervous system.
Zhiyi Zuo, Jiejie Li, Chenzhuo Feng
doaj   +1 more source

Challenges in Physiological Phenotyping of hiPSC-Derived Neurons: From 2D Cultures to 3D Brain Organoids

open access: yesFrontiers in Cell and Developmental Biology, 2020
Neurons derived from human induced pluripotent stem cells (hiPSC-derived neurons) offer novel opportunities for the development of preclinical models of human neurodegenerative diseases (NDDs).
Pedro Mateos-Aparicio   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences [PDF]

open access: yes, 2005
We investigated the role of GABAergic inhibition on the responses of inferior colliculus (IC) neurons sensitive to interaural time differences (ITDs) in anesthetized guinea pigs.
Ingham, NJ, Mcalpine, D
core  

A systematic method for configuring VLSI networks of spiking neurons [PDF]

open access: yes, 2011
Neftci E, Chicca E, Indiveri G, Douglas RJ. A systematic method for configuring VLSI networks of spiking neurons. Neural Computation. 2011;23(10):2457-2497.An increasing number of research groups are developing custom hybrid analog/digital very large ...
Rodney Douglas   +19 more
core   +1 more source

Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

open access: yesNeural Regeneration Research, 2015
Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons

open access: yesApplied Sciences, 2019
Here we demonstrate that human neural stem cells (NSCs) proliferate while in space and they express specific NSC markers after being in space. NSCs displayed both higher oxygen consumption and glycolysis than ground controls.
Carlos Cepeda   +6 more
doaj   +1 more source

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