Results 101 to 110 of about 130,277 (309)

Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline

Case Reports in Medicine, 2012
Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. We
David J. Kopsky, Remko Liebregts, Jan M. Keppel Hesselink   +2 more
doaj   +1 more source

Role of Duloxetine in management of cervical or lumbosacral neuralgia of unknown etiology: A preliminary study

Indian Journal of Pain, 2013
Background: Duloxetine is a selective serotonin reuptake inhibitor (SSRI) used for treatment of neuropathic pain associated with diabetic neuropathy and fibromyalgia. Use of duloxetine for idiopathic neuropathic pain is not known.
Digambar P Nawani, Sanjay Agrawal, Veena Asthana   +2 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Differential drug effects on spontaneous and evoked pain behavior in a model of trigeminal neuropathic pain

Journal of Pain Research, 2017
K Deseure,1 GH Hans2 1Department of Medicine, Laboratory for Pain Research, University of Antwerp, Wilrijk, 2Multidisciplinary Pain Center, Antwerp University Hospital, Edegem, Belgium Purpose: Baclofen and morphine have shown efficacy against ...
Deseure K, Hans GH
doaj  

Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

eLife, 2018
Neuropathic pain resulting from nerve injury can become persistent and difficult to treat but the molecular signaling responsible for its development remains poorly described.
Josette J Wlaschin, Jacob M Gluski, Eileen Nguyen, Hanna Silberberg, James H Thompson, Alexander T Chesler, Claire E Le Pichon   +6 more
doaj   +1 more source

Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

, 2014
The auxiliary α2δ-1 subunit of voltage-gated calcium channels is up-regulated in dorsal root ganglion neurons following peripheral somatosensory nerve damage, in several animal models of neuropathic pain.
Sandhu, G, Bauer, CS, Dolphin, AC, Jiruska, P., Jefferys, J.G.R., Nieto-Rostro, M., Sandhu, G., Dolphin, A.C., Bauer, C.S., Jiruska, P, Nieto-Rostro, M, Jefferys, JG   +11 more
core   +1 more source

Implant‐related orofacial pain managed with implant apicoectomy: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background In recent years, the use of implants has emerged as a widely accepted method for the replacement of missing teeth. Although rare, chronic pain associated with implant placement has been reported in the literature. Conversely, apicoectomy, the removal of the apical portion has been integrated into the implantology field in cases with
Oscar Durán‐Garnica, Karen Villarreal‐Arizpe, Hong Chen, Hsun‐Liang Chan, Guo‐Liang Cheng   +4 more
wiley   +1 more source

Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain

Frontiers in Neuroscience
IntroductionMany forms of chronic pain remain refractory to existing pharmacotherapies and electrical neuromodulation. We have recently reported the clinical efficacy of a novel form of analgesic electrical neuromodulation that uses ultra low frequency ...
Martyn G. Jones, Martyn G. Jones, Liam A. Matthews, Liam A. Matthews, Scott Lempka, Scott Lempka, Scott Lempka, Nishant Verma, James P. Harris, Stephen B. McMahon   +9 more
doaj   +1 more source

Pain in the Blood? Envisioning Mechanism-Based Diagnoses and Biomarkers in Clinical Pain Medicine

Diagnostics, 2015
Chronic pain is highly prevalent, and pain medicine lacks objective biomarkers to guide diagnosis and choice of treatment. The current U.S. “opioid epidemic” is a reminder of the paucity of effective and safe treatment options. Traditional pain diagnoses
Emmanuel Bäckryd
doaj   +1 more source

Neurophysiological and histopathological evaluation of small fiber pathways as diagnostic characterization of neuropathic pain and autonom dysfunction syndromes

, 2012
This manuscript is made up of two individual not related articles about peripheral neuropathic pain syndrome. The first article reports the effect on pain relief in patients with peripheral neuropathic pain after brachial plexus lesions or distal ...
Devigli, Grazia, Devigili, Grazia
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