Results 221 to 230 of about 130,277 (309)

Commentary on central sensitization in chronic pelvic pain

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Shahzadi Gulfishan, Ahmed Raza, Abdullah Aman   +2 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Effectiveness of Total Contact Casting in the Treatment of Neuropathic Plantar Ulcers: An Observational Study. [PDF]

Cureus
Kataruka M, Sannyashi P, Bhattacharjee S, Sajeev A.   +3 more
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

STING Modulating ER-Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity. [PDF]

CNS Neurosci Ther
Liu Y, Yang X, Kuai S, Chen X, Wang Z, Yang Z, Guo X, He X, Zhao P.   +8 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders. [PDF]

Mil Med Res
Li L, Han Q, Bai HL, Xiao Q, He X, Chen JF, Zhen ZM, Luo XQ, Zhang YJ, Lu MM, Wang X, Li SY, Xiong JX, Wang Y, Hu ZA, Zhang XL, Liu Y, He C.   +17 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

The intrinsic reason why it is relevant to introduce the concept of "small fiber neuralgia" into the taxonomy of pain disorders. [PDF]

Front Pain Res (Lausanne)
Lefaucheur JP.
europepmc   +1 more source