Results 21 to 30 of about 130,277 (309)

Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

eLife, 2021
The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to the
Robert AR Drake, Kenneth A Steel, Richard Apps, Bridget M Lumb, Anthony E Pickering   +4 more
doaj   +1 more source

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids [PDF]

, 2010
Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Julia Metzner, Ziebell, Simone, Koch, Marco, Myrczek, Thekla, Marian, Claudiu, Dehghani, Faramarz, Rohini Kuner, Schmidt Helmut, Bechmann Ingo, Marian Claudiu, Nina Wijnvoord, Dehghani Faramarz, Philipp Bishay, Bishay, Philipp, Kuner, Rohini, Helmut Schmidt, Faramarz Dehghani, Koch Marco, Bechmann, Ingo, Metzner, Julia, Geisslinger Gerd, Irmgard Tegeder, Tegeder Irmgard, Simone Ziebell, Wijnvoord, Nina, Tegeder, Irmgard, Claudiu Marian, Kuner Rohini, Costigan, Michael, Wijnvoord Nina, Annett Häussler, Ingo Bechmann, Michael Costigan, Schmidt, Helmut, Häussler, Annett, Bechmann, Ingo Jürgen, Myrczek Thekla, Bishay Philipp, Häussler Annett, Marco Koch, Costigan Michael, Thekla Myrczek, Metzner Julia   +45 more
core   +1 more source

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Case Reports in Medicine, 2011
A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Neuropathic pain treatment: still a challenge

Neurology International, 2016
Neuropathic pain (NP) is the result of a series of conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of NP pathophysiology previously unexplored therapies have been used with encouraging results.
Osvaldo J.M. Nascimento, Bruno L. Pessoa, Marco Orsini, Pedro Ribeiro, Eduardo Davidovich, Camila Pupe, Pedro Moreira Filho, Ricardo Menezes Dornas, Lucas Masiero, Juliana Bittencourt, Victor Hugo Bastos   +10 more
doaj   +1 more source

Learning and memory with neuropathic pain : impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Irmgard eTegeder, Vannoni, Elisabetta, Annett eHäussler, Irmgard Tegeder, Wolfer, David P., Elisabetta Vannoni, David P. Wolfer, Tegeder, Irmgard, Wolfer, David P, Elisabetta eVannoni, Annett Häussler, Häussler, Annett, Boris eAlbuquerque, Boris Albuquerque, Albuquerque, Boris, David P Wolfer, Wolfer, David Paul; id_orcid   +16 more
core   +1 more source

Association between medically assisted detoxification and neuropathic pain [PDF]

, 2021
High-risk alcohol use is correlated with chronic pain. Chronic pain and alcohol dependence are associated with similar neurological, endocrinological and behavioural patterns, and it has been hypothesised that symptoms of neuropathic pain are exacerbated
Wilson, Iain, Thompson, Trevor
core   +1 more source

Chronic postsurgical pain in children and young adults with cancer and choice of regional anesthesia for amputation and limb‐sparing surgery

Cancer Reports, 2023
Background Patients undergoing limb amputation (LA) or limb‐sparing (LS) for lower extremity oncologic diagnoses are at similar risk for chronic postsurgical pain of neuropathic nature (CPSP/NP).
Doralina L. Anghelescu, Emma Johns, Shalini Bhatia, Michael J. Frett, Zhaohua Lu   +4 more
doaj   +1 more source

Neuropathic Pain

Seminars in Neurology, 2016
Diagnosing neuropathic pain and distinguishing it from nociceptive pain can be challenging, but is essential because both forms of pain require different treatment strategies. The diagnosis of neuropathic pain is primarily based on clinical findings.
Janne, Gierthmühlen, Ralf, Baron
openaire   +5 more sources

Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support?

Case Reports in Medicine, 2015
Baclofen 5% cream can be used for the treatment of neuropathic pain. We describe an unusual case of a neuropathic pain patient with spinal cord injury.
David J. Kopsky, Jan M. Keppel Hesselink, Roberto Casale   +2 more
doaj   +1 more source

Analgesia for acute pain

South African Family Practice, 2016
Acute pain is known to every person universally, and the management of pain is one of the biggest industries in the world today. There are many and varied options to achieve analgesia, but if not used for the correct indication, if not initiated ...
R. van Rensburg
doaj   +1 more source