Results 171 to 180 of about 1,846,055 (403)

Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway–produced analgesic effect in a trigeminal neuropathic pain mouse model

Pain, 2018
Neuropathic pain represents a challenge to clinicians because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway–mediated modulation of trigeminal neuropathic ...
Sufang Liu, Yuanyuan Tang, H. Shu, D. Tatum, Q. Bai, J. Crawford, Ying Xing, M. Lobo, L. Bellinger, P. Kramer, F. Tao   +10 more
semanticscholar   +1 more source

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

Diagnostics and therapy of peripheral neuropathy (literature review)

Acta Biomedica Scientifica, 2015
The review is devoted to diagnostics and treatment of neuropathic pain in patients with peripheral nervous system diseases. Main assessment tools are shown including Visual analog Scale (VAS), Neuropathic Pain Scale (NPS), Leeds Assessment of Neuropathic
G. Y. Levina, Y. N. Bykov, A. S. Borisov
doaj  

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Neuropathic Pain due to Small Fiber Neuropathy in Aging: Current Management and Future Prospects [PDF]

, 2015
Brigitte A. Brouwer, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Margot Geerts, Maarten van Kleef, Ingemar S. J. Merkies, Catharina G. Faber   +6 more
openalex   +1 more source

Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain

, 2023
Kimberly Gómez, Heather N. Allen, Paz Duran, Santiago Loya‐López, Aida Calderón‐Rivera, Aubin Moutal, Cheng Tang, Tyler S. Nelson, Samantha Perez‐Miller, Rajesh Khanna   +9 more
openalex   +2 more sources

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Ultramicronized N-palmitoylethanolamine Contributes to MorphineEfficacy Against Neuropathic Pain: Implication of Mast Cells and Glia [PDF]

, 2022
Laura Micheli, Elena Lucarini, Stefania Nobili, Gianluca Bartolucci, Marco Pallecchi, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +9 more
openalex   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Pain Catastrophizing Predicts Poor Response to Topical Analgesics in Patients with Neuropathic Pain

Pain Research and Management, 2012
The prevalence of neuropathic pain approaches 10% in Canada and the United States. Given the aging population and the increasing survival rates following interventions for neuropathic pain, the prevalence of neuropathic pain conditions is expected to ...
Tsipora Mankovsky, Mary E Lynch, AJ Clark, J Sawynok, Michael JL Sullivan   +4 more
doaj   +1 more source