Results 301 to 310 of about 1,846,055 (403)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Research Progress on the Mechanism of Ketamine in Neuropathic Pain Comorbid Depression. [PDF]

Neuropsychiatr Dis Treat
Li Q, Liu S, Qin B, Liu X.
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Radiotherapy dosimetry oversights in the RELAX trial: implications for interpreting taVNS efficacy in neuropathic pain. [PDF]

EClinicalMedicine
Di Y, Li J, Meng L.
europepmc   +1 more source

Activation of GPR55 alleviates neuropathic pain and chronic inflammation [PDF]

Weiqun Jiang, Wenbin Yu, Yu Tan
openalex   +1 more source

A complex network perspective on brain disease

Biological Reviews, EarlyView.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

S-ketamine relieves neuropathic pain by inhibiting microglia phagocytosis of the perineuronal nets. [PDF]

Sci Rep
Yang X, Wang Y, Jiang L, Huang S, Jiao Y, Wu Q, Zhang Y, Huang Y, Gu X, Xu R, Zhang W, Ma Z.   +11 more
europepmc   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Refractory Neuropathic Pain in the Head and Neck: Neuroanatomical and Clinical Significance of the Cervicotrigeminal Complex. [PDF]

Life (Basel)
Raguž M, Tarle M, Hat K, Salarić I, Marčinković P, Bičanić I, Lazić Mosler E, Lukšić I, Marinović T, Chudy D.   +9 more
europepmc   +1 more source

Sensory network dysregulation in type 2 diabetes: Linking olfactory, visual, and cognitive function

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study investigates the relationship between multisensory (visual, somatosensory, and olfactory) dysfunction and cognitive decline in Type 2 diabetes (T2D), with a particular focus on the mediating role of olfactory dysfunction. Methods We used resting‐state fMRI to assess seed‐based functional connectivity from the primary sensory ...
Qian Li, Xin Li, Yan Bi, Jiaming Lu, Yi Zhang, Min Wu, Xinyi Shen, Zhengyang Zhu, Xin Zhang, Yining Chao, Zhou Zhang, Wen Zhang, Bing Zhang   +12 more
wiley   +1 more source