Results 11 to 20 of about 174,921 (327)

Neuropathology of stress [PDF]

Acta Neuropathologica, 2013
Environmental challenges are part of daily life for any individual. In fact, stress appears to be increasingly present in our modern, and demanding, industrialized society. Virtually every aspect of our body and brain can be influenced by stress and although its effects are partly mediated by powerful corticosteroid hormones that target the nervous ...
Lucassen, P.J., Pruessner, J., Sousa, N., Almeida, O.F.X., van Dam, A.M., Rajkowska, G., Swaab, D.F., Czéh, B.   +7 more
openaire   +7 more sources

Neuroinflammation and neuropathology

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2021
This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented.
Esin R.G., Safina D.R., Khakimova A.R., Esin O.R.   +3 more
openaire   +4 more sources

Chronic Traumatic Encephalopathy as a Preventable Environmental Disease

Frontiers in Neurology, 2022
In this Perspective we explore the evolution of our understanding of chronic traumatic encephalopathy (CTE) and its relationship with repetitive head injury.
Michael E. Buckland, Michael E. Buckland, Andrew J. Affleck, Alan J. Pearce, Catherine M. Suter, Catherine M. Suter   +5 more
doaj   +1 more source

Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis

Biology, 2022
The neuropathological hallmark of amyotrophic lateral sclerosis (ALS) is motor neuron degeneration in the spinal cord and cortex. Accumulating studies report that other neurons in the central nervous system (CNS) are also affected in ALS.
Justin You, Katarina Maksimovic, Jooyun Lee, Mashiat Khan, Rintaro Masuda, Jeehye Park   +5 more
doaj   +1 more source

The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. [PDF]

, 2016
The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing
Calton, Michele A, Goldowitz, Dan, Harper, Ronald M, Howard, Jeremy R, Mittleman, Guy   +4 more
core   +2 more sources

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]

, 2020
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia, Cunha-Santos, Janete, Gaspar, Laetitia S., Greif, Hagar, Nobre, Rui Jorge, Nóbrega, Clévio, Paixão, Susana, Pereira de Almeida, Luís, Santana, Magda M., Silva, Teresa Pereira, Trevino-Garcia, Allyson   +10 more
core   +1 more source

Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains

NeuroSci, 2022
Thioredoxin-Interacting Protein (TXNIP) has been shown to have significant pathogenic roles in many human diseases, particularly those associated with diabetes and hyperglycemia. Its main mode of action is to sequester thioredoxins, resulting in enhanced
Haruka Tsubaki, Anarmaa Mendsaikhan, Undral Buyandelger, Ikuo Tooyama, Douglas G. Walker   +4 more
doaj   +1 more source

A case of recurrent epilepsy-associated rosette-forming glioneuronal tumor with anaplastic transformation in the absence of therapy. [PDF]

, 2019
Rosette-forming glioneuronal tumor (RGNT) most commonly occurs adjacent to the fourth ventricle and therefore rarely presents with epilepsy. Recent reports describe RGNT occurrence in other anatomical locations with considerable morphologic and genetic ...
Corless, Christopher L, Ferris, Sean P, Grafe, Marjorie, Gultekin, Sakir H, Halfpenny, Aaron, Lawce, Helen, Lucas, Lora, Moore, Stephen, Nazemi, Kellie, Olson, Susan, Perry, Arie, Selden, Nathan, Solomon, David A, Woltjer, Randy, Wood, Matthew D   +14 more
core   +1 more source

Neuropathology of Animal Prion Diseases

Biomolecules, 2021
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals.
Leonor Orge, Carla Lima, Carla Machado, Paula Tavares, Paula Mendonça, Paulo Carvalho, João Silva, Maria de Lurdes Pinto, Estela Bastos, Jorge Cláudio Pereira, Nuno Gonçalves-Anjo, Adelina Gama, Alexandra Esteves, Anabela Alves, Ana Cristina Matos, Fernanda Seixas, Filipe Silva, Isabel Pires, Luis Figueira, Madalena Vieira-Pinto, Roberto Sargo, Maria dos Anjos Pires   +21 more
doaj   +1 more source

One-hundred years (and counting) of blast-associated traumatic brain injury [PDF]

, 2018
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks.
Fullerton, Josephine L., Kinch, Kevin, Stewart, William   +2 more
core   +1 more source