Results 21 to 30 of about 115,701 (249)

YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma

Journal of Hematology & Oncology, 2021
Background The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N6 ...
Rui-Chao Chai, Yu-Zhou Chang, Xin Chang, Bo Pang, Song Yuan An, Ke-Nan Zhang, Yuan-Hao Chang, Tao Jiang, Yong-Zhi Wang   +8 more
doaj   +1 more source

Neuropathology as a Life-Task [PDF]

, 2020
Neuropathology as a special field in medicine saw its development not until the second half of the twentieth century. Its roots are in neurology and pathology. Its significance has risen because of the emergence of neurosurgergy.
Jänisch, Werner
core   +1 more source

Loss of PIKfyve drives the spongiform degeneration in prion diseases

EMBO Molecular Medicine, 2021
Brain‐matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown. Here, we report that prion infection and prion‐mimetic antibodies deplete the phosphoinositide kinase PIKfyve—which controls endolysosomal maturation—from mouse
Asvin K K Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi   +6 more
doaj   +1 more source

The Neuropathology of Autoimmune Ataxias

, 2022
Autoimmune-mediated ataxia has been associated with paraneoplastic disease, gluten enteropathy, Hashimoto thyroiditis as well as autoimmune disorders without a known associated disease. There have been relatively few reports describing the neuropathology
H. Brent Clark
core   +1 more source

Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis

Biology, 2022
The neuropathological hallmark of amyotrophic lateral sclerosis (ALS) is motor neuron degeneration in the spinal cord and cortex. Accumulating studies report that other neurons in the central nervous system (CNS) are also affected in ALS.
Justin You, Katarina Maksimovic, Jooyun Lee, Mashiat Khan, Rintaro Masuda, Jeehye Park   +5 more
doaj   +1 more source

Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains

NeuroSci, 2022
Thioredoxin-Interacting Protein (TXNIP) has been shown to have significant pathogenic roles in many human diseases, particularly those associated with diabetes and hyperglycemia. Its main mode of action is to sequester thioredoxins, resulting in enhanced
Haruka Tsubaki, Anarmaa Mendsaikhan, Undral Buyandelger, Ikuo Tooyama, Douglas G. Walker   +4 more
doaj   +1 more source

Neuropathology of Animal Prion Diseases

Biomolecules, 2021
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals.
Leonor Orge, Carla Lima, Carla Machado, Paula Tavares, Paula Mendonça, Paulo Carvalho, João Silva, Maria de Lurdes Pinto, Estela Bastos, Jorge Cláudio Pereira, Nuno Gonçalves-Anjo, Adelina Gama, Alexandra Esteves, Anabela Alves, Ana Cristina Matos, Fernanda Seixas, Filipe Silva, Isabel Pires, Luis Figueira, Madalena Vieira-Pinto, Roberto Sargo, Maria dos Anjos Pires   +21 more
doaj   +1 more source

Neuropathology in mice expressing mouse alpha-synuclein [PDF]

, 2011
?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J., Ksiazek, Iwona, Derya R Shimshek, Markus A Ruegg, Rieker Claus, Cindy Boden, Ruegg Markus A., Derya R. Shimshek, Dev, Kumlesh K., Simone Danner, Heinrich Schell, Herman van der Putten, Claus Rieker, Ruegg, Markus A., Philipp J Kahle, Iwona Ksiazek, Boden Cindy, Kumlesh K Dev, Sabine Kauffmann, Schell, Heinrich, van der Putten Herman, Kauffmann Sabine, Dev Kumlesh K., Kumlesh K. Dev, Shimshek, Derya R., Lehnhoff Katja, Ksiazek Iwona, Katja Lehnhoff, Shimshek Derya R., Schell Heinrich, Rieker, Claus, Samuel Barbieri, Philipp J. Kahle, van der Putten, Herman, Kauffmann, Sabine, Lehnhoff, Katja, Markus A. Ruegg, Kahle Philipp J., Danner, Simone, Barbieri, Samuel, Danner Simone, Boden, Cindy, Barbieri Samuel   +42 more
core   +2 more sources

Neuropathological characterization of the cavitating leukoencephalopathy caused by COA8 cytochrome c oxidase deficiency: a case report

Frontiers in Cellular Neuroscience, 2023
COA8-related leukoencephalopathy is a recently described rare cavitating leukoencephalopathy caused by biallelic variants in the COA8 gene. Clinically, it presents heterogeneously and usually follows a bi-phasic clinical course with a period of acute ...
Alexandra Chapleau, Alexandra Chapleau, Renée-Myriam Boucher, Tomi Pastinen, Tomi Pastinen, Isabelle Thiffault, Isabelle Thiffault, Isabelle Thiffault, Peter V. Gould, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard   +13 more
doaj   +1 more source

The role of sex differences in depression in pathologically defined Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
IntroductionSex differences in Alzheimer’s disease (AD) may contribute to disease heterogeneity and affect prevalence, risk factors, disease trajectories and outcomes. Depression impacts a large number of patients with AD and has been reported to be more
Cécilia Tremblay, Parichita Choudhury, Christine M. Belden, Danielle Goldfarb, Ileana Lorenzini, Thomas G. Beach, Geidy E. Serrano   +6 more
doaj   +1 more source