Results 41 to 50 of about 171,935 (300)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A Systematic Approach to Dissection of the Equine Brain–Evaluation of a Species-Adapted Protocol for Beginners and Experts

Frontiers in Neuroanatomy, 2020
Introduction of new imaging modalities for the equine brain have refocused attention on the horse as a natural model for ethological, neuroanatomical, and neuroscientific investigations.
Maya-Lena Bitschi, Zoltán Bagó, Marco Rosati, Sven Reese, Lutz S. Goehring, Kaspar Matiasek   +5 more
doaj   +1 more source

No Metagenomic Evidence of Causative Viral Pathogens in Postencephalitic Parkinsonism Following Encephalitis Lethargica

Microorganisms, 2021
Postencephalitic parkinsonism (PEP) is a disease of unknown etiology and pathophysiology following encephalitis lethargica (EL), an acute-onset polioencephalitis of cryptic cause in the 1920s. PEP is a tauopathy with multisystem neuronal loss and gliosis,
Dániel Cadar, Kurt A. Jellinger, Peter Riederer, Sabrina Strobel, Camelia-Maria Monoranu, Dennis Tappe   +5 more
doaj   +1 more source

Progression of extrapyramidal signs in Alzheimer's disease. clinical and neuropathological correlates [PDF]

, 2015
Extrapyramidal signs (EPS) are frequent in Alzheimer's disease (AD) and core manifestation of related diseases, i.e., dementia with Lewy bodies and Parkinson's disease; furthermore, Lewy bodies and AD-type pathology occur in all three ...
Bruno, Giuseppe, Hawes, Stephen E, Mayeux, Richard, Monsell, Sarah E, Tosto, Giuseppe   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Curdlan, a Microbial β-Glucan, Has Contrasting Effects on Autoimmune and Viral Models of Multiple Sclerosis

Frontiers in Cellular and Infection Microbiology, 2022
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelination and axonal degeneration in the central nervous system (CNS).
Fumitaka Sato, Fumitaka Sato, Yumina Nakamura, Aoshi Katsuki, Sundar Khadka, Ijaz Ahmad, Seiichi Omura, Seiichi Omura, Nicholas E. Martinez, Ikuo Tsunoda, Ikuo Tsunoda   +10 more
doaj   +1 more source

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. [PDF]

, 2015
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed
Alvarez, Victor E, Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dams-O'Connor, Kristen, Dickson, Dennis W, Folkerth, Rebecca D, Gordon, Wayne A, Keene, C Dirk, Litvan, Irene, McKee, Ann C, Perl, Daniel P, Stein, Thor D, Stewart, William, TBI/CTE group, Tripodis, Yorghos, Vonsattel, Jean-Paul   +16 more
core   +3 more sources

Neuropathology [PDF]

Journal of Neuropathology and Experimental Neurology, 1998
Cerebral spinal fluid - cytology tumours - applications of light microscopic methods tumours - applications of ultrastructural methods tumours - applications of immunocytochemical methods tumours of the pituitary region vascular diseases bacterial, fungal, protozoal and parasitic infections viral infections AIDS and the central nervous system ...
openaire   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

69th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) - Meeting Abstracts, September 25–27, 2025

Free Neuropathology
Sehr geehrte Damen und Herren, liebe Kolleginnen und Kollegen, im Namen der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie heiße ich Sie herzlich willkommen zur 69.
German Society of Neuropathology and Neuroanatomy (DGNN)
doaj   +1 more source