Results 61 to 70 of about 115,701 (249)

Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum

Frontiers in Neurology, 2023
IntroductionThe measurement of neurofilament light chain (NfL) in blood is a promising biomarker of neurological injury and disease. We investigated the genetic factors that underlie serum NfL levels (sNfL) of individuals without neurological conditions ...
Marisol Herrera-Rivero, Edith Hofer, Edith Hofer, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Reinhold Schmidt, Michael Khalil, Heinz Wiendl, Monika Stoll, Monika Stoll, Klaus Berger   +12 more
doaj   +1 more source

Mixed neuropathology in frontotemporal lobar degeneration [PDF]

, 2020
Aim: Frontotemporal lobar degeneration (FTLD) is a significant cause of dementia in mid-life and older adults. The extent of interactions between FTLD and other neurodegenerative pathologies is unclear.
Pennington, Catherine; id_orcid, Coulthard, Elizabeth, Love, Seth, Marini, Luca, Pennington, Catherine   +4 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Macroscopic and Microscopic Cerebral Findings in Drug and Alcohol Abusers: The Point of View of the Forensic Pathologist

Biomedicines
Drug abuse still represents a significant challenge for forensic pathologists; it must always be considered during the autopsy examination when the brain morphological alterations observed are not characteristic of any known disease of the central ...
Angelo Montana, Letizia Alfieri, Margherita Neri, Denise Piano, Eva Renier, Matteo Marti, Marco Palpacelli, Giuseppe Basile, Giovanni Tossetta, Francesco Paolo Busardò   +9 more
doaj   +1 more source

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

Frontiers in Aging Neuroscience, 2017
Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while blocking CSF-1R can lead to rapid microglia cell death.
Douglas G. Walker, Douglas G. Walker, Tiffany M. Tang, Lih-Fen Lue, Lih-Fen Lue   +4 more
doaj   +1 more source

Neuropathology.

, 2018
Neuropathological analysis of brains from newborn piglets 9.5 h after hypoxia-ischemia treated with VEH, DHA, VEH + HT and DHA + HT. a) Percentage of animals with damaged cells (neuropathology score grade 1–4).
Javier Escobar (307104), Rønnaug Solberg (252034), Else Marit Løberg (359028), Marianne Ullestad Huun (5608088), Jose Martinez-Orgado (5608094), Håvard Garberg (5608091), Ola Didrik Saugstad (359032)   +6 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking

Cells
Miro GTPases are key components in the machinery responsible for transporting mitochondria and peroxisomes along microtubules, and also play important roles in regulating calcium homeostasis and organizing contact sites between mitochondria and the ...
Pontus Aspenström
doaj   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Pathomorphological parameters of sepsis-associated encephalopathy in deceased septic patients without purulent lesions to the brain

Сучасні медичні технології
Sepsis-associated encephalopathy (SAE) clinically manifests by delirium and decreased consciousness less than 15 points on Glasgow Coma Scale. SAE pathophysiology includes neuroinflammation, ischemic-hypoxic and dysmetabolic mechanisms.
T. V. Shulyatnikova, L. M. Tumanska
doaj   +1 more source