Results 1 to 10 of about 95,709 (300)

Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS).
Rana Zakaria Ahmed Mohamed, Haitham Hamdy Salem, Hossam Moussa El-Sayed Sakr, Hossam-Eldin Mahmoud Afifi, Ahmed Mohammed Elsadek, Nagia Aly Fahmy   +5 more
doaj   +1 more source

Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS. [PDF]

PLoS ONE, 2011
The changes in the cerebrospinal fluid (CSF) metabolome associated with the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) are poorly understood and earlier smaller studies have shown conflicting results.
Anna Wuolikainen, Thomas Moritz, Stefan L Marklund, Henrik Antti, Peter Munch Andersen   +4 more
doaj   +1 more source

MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis

Data in Brief, 2020
A standardised imaging protocol was implemented to evaluate disease burden in specific thalamic and amygdalar nuclei in 133 carefully phenotyped and genotyped motor neuron disease patients.
Rangariroyashe H. Chipika, We Fong Siah, Stacey Li Hi Shing, Eoin Finegan, Mary Clare McKenna, Foteini Christidi, Kai Ming Chang, Efstratios Karavasilis, Alice Vajda, Jennifer C. Hengeveld, Mark A. Doherty, Colette Donaghy, Siobhan Hutchinson, Russell L. McLaughlin, Orla Hardiman, Peter Bede   +15 more
doaj   +1 more source

Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

Журнал инфектологии, 2018
We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is ...
T. M. Alekseeva, N. V. Skripchenko, S. V. Lobzin, V. S. Demeshonok, E. A. Yurkina, V. D. Nazarov, S. V. Lapin   +6 more
doaj   +1 more source

Motoneuron firing in amyotrophic lateral sclerosis (ALS) [PDF]

Frontiers in Human Neuroscience, 2014
Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia.
Carvalho, Mamede, Eisen, Andrew, Krieger, Charles, Swash, Michael   +3 more
openaire   +4 more sources

Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors [PDF]

Frontiers in Pharmacology, 2018
In the present review we discuss the potential involvement of adenosinergic signaling, in particular the role of adenosine receptors, in amyotrophic lateral sclerosis (ALS). Though the literature on this topic is not abundant, the information so far available on adenosine receptors in animal models of ALS highlights the interest to continue to explore ...
Ana M. Sebastião, Ana M. Sebastião, Nádia Rei, Nádia Rei, Joaquim A. Ribeiro, Joaquim A. Ribeiro   +5 more
openaire   +4 more sources

Dysphagia in amyotrophic lateral sclerosis: impact on patient behavior, diet adaptation, and riluzole management [PDF]

, 2017
This retrospective study aimed to investigate the clinical features associated with deteriorated swallow in amyotrophic lateral sclerosis (ALS) patients with spinal and bulbar onset, describe the modification of diet and liquid intake, and assess the ...
CAMBIERI, CHIARA, CECCANTI, MARCO, FRASCA, VITTORIO, Gori, Mc, INGHILLERI, Maurizio, ONESTI, EMANUELA, RUOPPOLO, Giovanni, SCHETTINO, ILENIA   +7 more
core   +1 more source

Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS) [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor neurons, although there is marked phenotypic heterogeneity between cases. Typical, or "classical," ALS is associated with simultaneous upper motor neuron (UMN) and lower motor neuron (LMN) involvement at disease onset, whereas atypical forms, such as primary ...
Grad, Leslie, Rouleau, Guy, Ravits, John, Cashman, Neil   +3 more
openaire   +4 more sources

Dysphagia as the Initial Presenting Symptom of Amyotrophic Lateral Sclerosis

Philippine Journal of Otolaryngology Head and Neck Surgery, 2008
Objective:  To present a case of Amyotrophic Lateral Sclerosis (ALS) with an unusual initial presentation of dysphagia. Methods: Design:  Case Report Setting:  Private tertiary university hospital Patient:  One Results:  A 78-year-old ...
Adrian F. Fernando, Antonio H. Chua
doaj   +1 more source

Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Stem Cell Research, 2020
Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS).
Baofeng Feng, Jun Ma, Asiamah Ernest Amponsah, Ruiyun Guo, Desheng Kong, Jingjing He, Yawen Jiang, Wei Zhang, Zhanchi Zhang, Yongzhou Song, Sanbing Shen, Timothy O'Brien, Huixian Cui   +12 more
doaj   +1 more source