Results 1 to 10 of about 49,177 (260)

Drug repurposing in amyotrophic lateral sclerosis (ALS). [PDF]

Expert Opin Drug Discov
Identifying treatments that can alter the natural history of amyotrophic lateral sclerosis (ALS) is challenging. For years, drug discovery in ALS has relied upon traditional approaches with limited success. Drug repurposing, where clinically approved drugs are reevaluated for other indications, offers an alternative strategy that overcomes some of the ...
Carroll E, Scaber J, Huber KVM, Brennan PE, Thompson AG, Turner MR, Talbot K.   +6 more
europepmc   +3 more sources

Motor Neuron Disease: The Contribution of TAR-43 Gene in Amyotrophic Lateral Sclerosis [PDF]

Bengal Physician Journal, 2023
Motor neuron diseases are a spectrum of neurodegenerative disorders, characterized by their physicochemical propinquity for the voluntary motor systems. The most notorious of these neurodegenerative disorders is amyotrophic lateral sclerosis (ALS), which
Gorky Guha
doaj   +1 more source

Investigating the Effectiveness of Acceptance and Commitment Therapy on Perceived Social Support and Life Expectancy of Caregivers of Patients with Amyotrophic Lateral Sclerosis (ALS): A Case Study [PDF]

مجله علوم پزشکی صدرا, 2023
Introduction: Caring for patients with amyotrophic lateral sclerosis (ALS) presents numerous challenges that can significantly impact caregivers. These challenges necessitate interventions to increase perceived social support and improve life expectancy.
Royasadat Shavaran, Akram Dehghani Champiri   +1 more
doaj   +1 more source

Motoneuron firing in amyotrophic lateral sclerosis (ALS) [PDF]

Frontiers in Human Neuroscience, 2014
Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia.
Carvalho, Mamede, Eisen, Andrew, Krieger, Charles, Swash, Michael   +3 more
openaire   +4 more sources

High and Low Contrast Visual Acuity Are Not Affected in Amyotrophic Lateral Sclerosis. [PDF]

PLoS ONE, 2016
The afferent visual system may be affected by neuro-degeneration in amyotrophic lateral sclerosis (ALS) based on observations of visual function impairment and retinal inclusions on histopathology in ALS patients.
Heather E Moss, Monica Samelson, Girish Mohan, Qin Li Jiang   +3 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors [PDF]

Frontiers in Pharmacology, 2018
In the present review we discuss the potential involvement of adenosinergic signaling, in particular the role of adenosine receptors, in amyotrophic lateral sclerosis (ALS). Though the literature on this topic is not abundant, the information so far available on adenosine receptors in animal models of ALS highlights the interest to continue to explore ...
Ana M. Sebastião, Ana M. Sebastião, Nádia Rei, Nádia Rei, Joaquim A. Ribeiro, Joaquim A. Ribeiro   +5 more
openaire   +4 more sources

Early Referral to an ALS Center Reduces Several Months the Diagnostic Delay: A Multicenter-Based Study

Frontiers in Neurology, 2020
Objective: To analyze those factors contributing to the diagnostic delay in ALS.Methods: Consecutive ALS patients were categorized as those studied in departmental hospitals and those studied in a referral ALS center.
Marina Martínez-Molina, Marina Martínez-Molina, Herminia Argente-Escrig, Herminia Argente-Escrig, Margarita F. Polo, David Hervás, Marina Frasquet, Marina Frasquet, Victoria Cortés, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa   +16 more
doaj   +1 more source

Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis

Data in Brief, 2020
A standardised, single-centre, longitudinal imaging protocol was used to evaluate longitudinal brainstem alterations in 100 patients with amyotrophic lateral sclerosis (ALS) with reference to 33 patients with primary lateral sclerosis (PLS), 30 patients ...
Peter Bede, Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Kai Ming Chang, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman   +11 more
doaj   +1 more source

Case report: A variant of the FIG4 gene with rapidly progressive amyotrophic lateral sclerosis

Frontiers in Neurology, 2022
Heterozygous autosomal-dominant FIG4 mutations are associated with amyotrophic lateral sclerosis (ALS). Here, we describe a variant of the FIG4 gene (c.350dupC, p.Asp118GlyfsTer9) in a patient with rapidly progressive ALS that has not previously been ...
Mubalake Yilihamu, Mubalake Yilihamu, Mubalake Yilihamu, Xiaolu Liu, Xiaolu Liu, Xiaolu Liu, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Yong Chen, Yong Chen, Yong Chen, Dongsheng Fan, Dongsheng Fan, Dongsheng Fan   +14 more
doaj   +1 more source

Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS) [PDF]

International Journal of Molecular Sciences, 2021
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disease. This adipokine has previously been shown to be associated with a lower risk of ALS and to confer a survival advantage in ALS patients. However, the role of leptin in the progression of ALS is unknown. Indeed, our understanding
Agueda Ferrer-Donato, Ana Contreras, Laura M. Frago, Julie A. Chowen, Carmen M. Fernandez-Martos   +4 more
openaire   +5 more sources