Results 21 to 30 of about 49,177 (260)

Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: Evidence from quantitative imaging data

Data in Brief, 2020
Primary lateral sclerosis and amyotrophic lateral sclerosis are primarily associated with motor cortex and corticospinal tract pathology. A standardised, prospective, single-centre neuroimaging protocol was used to characterise thalamic, hippocampal and ...
Eoin Finegan, Stacey Li Hi Shing, Rangariroyashe H. Chipika, Mary C. McKenna, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Colette Donaghy, Russell L. McLaughlin, Siobhan Hutchinson, Orla Hardiman, Peter Bede   +11 more
doaj   +1 more source

Identification of potentially functional modules and diagnostic genes related to amyotrophic lateral sclerosis based on the WGCNA and LASSO algorithms

Scientific Reports, 2022
Amyotrophic lateral sclerosis (ALS) is a genetically and phenotypically heterogeneous disease results in the loss of motor neurons. Mounting information points to involvement of other systems including cognitive impairment.
Narges Daneshafrooz, Masumeh Bagherzadeh Cham, Mohammad Majidi, Bahman Panahi   +3 more
doaj   +1 more source

SIGMAR1 variants in ALS–PD complex cases: a case report of a novel mutation and literature review

Frontiers in Neurology, 2023
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons, with occasional involvement of the extrapyramidal system.
Haining Li, Haining Li, Tingting Xuan, Tingting Xuan, Ting Xu, Juan Yang, Juan Yang, Jiang Cheng, Jiang Cheng, Zhenhai Wang, Zhenhai Wang   +10 more
doaj   +1 more source

Production and validation of human induced pluripotent stem cell line from sporadic amyotrophic lateral sclerosis (SALS)

Stem Cell Research, 2020
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the loss of upper motor neurons in the cortex and lower motor neurons in the brain stem and spinal cord regressively.
Jun Ma, Baofeng Feng, Desheng Kong, Jingjing He, Ruiyun Guo, Asiamah Ernest Amponsah, Wei Zhang, Shuhan Zhang, Fei Lv, Yongzhou Song, Aijing Liu, Huixian Cui   +11 more
doaj   +1 more source

Genetics of familial amyotrophic lateral sclerosis

Бюллетень сибирской медицины, 2021
To analyze results of the studies covering modern scientific views on the genetics of familial amyotrophic lateral sclerosis (FALS).We searched for full-text publications containing the key words “amyotrophic lateral sclerosis”, “FALS”, and “genetics” in
A. V. Savinova, N. A. Shnayder, R. F. Nasyrova   +2 more
doaj   +1 more source

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Cell Reports, 2019
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic mutations have been identified, the vast majority of ALS cases have no family history of ...
Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Delphine Fagegaltier, Brent T. Harris, Lyle W. Ostrow, Hemali Phatnani, John Ravits, Josh Dubnau, Molly Gale Hammell, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos.A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matt Harms, Eleonora Aronica, Mary Poss, Jennifer Phillips-Cremins, John Crary, Nazem Atassi, Dale J. Lange, Darius J. Adams, Leonidas Stefanis, Marc Gotkine, Robert Baloh, Suma Babu, Towfique Raj, Sabrina Paganoni, Ophir Shalem, Colin Smith, Bin Zhang, Brent T. Harris   +63 more
doaj   +1 more source

Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A tract of interest-based MRI study

NeuroImage: Clinical, 2018
Background: There is an ongoing debate whether primary lateral sclerosis (PLS) should be regarded as an independent disease entity separate from amyotrophic lateral sclerosis (ALS) or as a slowly progressive variant of ALS.
Hans-Peter Müller, Martin Gorges, Rebecca Kassubek, Johannes Dorst, Albert C. Ludolph, Jan Kassubek   +5 more
doaj   +1 more source

Familial amyotrophic lateral sclerosis and multiple sclerosis in an Egyptian family. A family report

Brain Disorders, 2023
Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are two neurological disorders with very different etiologies, genetic basis, clinical picture and prognosis. Thus their occurrence with in the same family is very unusual.
Radwa Soliman, Haitham Hamdy, Nagia Fahmy, Mahmoud S. Swelam   +3 more
doaj   +1 more source

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Nature Communications, 2020
Neuroimmune interactions are important in amyotrophic lateral sclerosis (ALS). Here the authors characterize the role of NK cells in mouse models of ALS, and in patient tissue.
Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard M. Ransohoff, Angela Santoni, Cristina Limatola   +11 more
doaj   +1 more source

Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)

eNeurologicalSci, 2020
Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan.
Peter S. Spencer, Valerie S. Palmer, Tameko Kihira, Sohei Yoshida, Jacques Reis, Momoko Yabushita, Yoshiro Yase   +6 more
doaj   +1 more source