Results 31 to 40 of about 2,700,197 (262)

CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
core   +1 more source

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Cell Reports, 2019
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic mutations have been identified, the vast majority of ALS cases have no family history of ...
Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Delphine Fagegaltier, Brent T. Harris, Lyle W. Ostrow, Hemali Phatnani, John Ravits, Josh Dubnau, Molly Gale Hammell, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos.A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matt Harms, Eleonora Aronica, Mary Poss, Jennifer Phillips-Cremins, John Crary, Nazem Atassi, Dale J. Lange, Darius J. Adams, Leonidas Stefanis, Marc Gotkine, Robert Baloh, Suma Babu, Towfique Raj, Sabrina Paganoni, Ophir Shalem, Colin Smith, Bin Zhang, Brent T. Harris   +63 more
doaj   +1 more source

Familial amyotrophic lateral sclerosis and multiple sclerosis in an Egyptian family. A family report

Brain Disorders, 2023
Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are two neurological disorders with very different etiologies, genetic basis, clinical picture and prognosis. Thus their occurrence with in the same family is very unusual.
Radwa Soliman, Haitham Hamdy, Nagia Fahmy, Mahmoud S. Swelam   +3 more
doaj   +1 more source

Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A tract of interest-based MRI study

NeuroImage: Clinical, 2018
Background: There is an ongoing debate whether primary lateral sclerosis (PLS) should be regarded as an independent disease entity separate from amyotrophic lateral sclerosis (ALS) or as a slowly progressive variant of ALS.
Hans-Peter Müller, Martin Gorges, Rebecca Kassubek, Johannes Dorst, Albert C. Ludolph, Jan Kassubek   +5 more
doaj   +1 more source

The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis [PDF]

, 2013
PMCID: PMC3631166This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Michael-Titus, A, Jayasinghe, M, Simon C. Dyall (404793), Biggio, M. L., Gladman, Stacy, Maria Luigia Biggio, Jayasinghe Maduka, Malaspina, A., Caterina Bendotti (202355), Pizzasegola Chiara, Simon C Dyall, Farhan Ullah (404792), Andrea Malaspina (315789), Biggio, ML, Pizzasegola, C, Stacy Gladman (404789), Pizzasegola, Chiara, Biggio Maria Luigia, Chiara Pizzasegola (404788), Gladman, S, Yip Ping K., Bendotti, C., Ullah, Farhan, Maria Luigia Biggio (404790), Bendotti, Caterina, Gladman Stacy, Ullah, F., Maduka Jayasinghe, Marino, M, Maduka Jayasinghe (404791), Dyall, SC, Malaspina, Andrea, Pizzasegola, C., Andrea Malaspina, Ullah Farhan, Chiara Pizzasegola, Ping K. Yip (247093), Dyall Simon C., Marianna Marino, Caterina Bendotti, Jayasinghe, M., Marino, Marianna, Marianna Marino (256589), Yip, P. K., Yip, PK, Bendotti, C, Malaspina Andrea, Gladman, S., Ullah, F, Marino Marianna, Michael-Titus, Adina, Bendotti Caterina, Adina Michael-Titus (404794), Jayasinghe, Maduka, Michael-Titus, A. T., Farhan Ullah, Ping K Yip, Biggio, Maria Luigia, Adina Michael-Titus, Dyall, Simon C; id_orcid, Stacy Gladman, Dyall, Simon, Michael-Titus Adina, Yip, Ping K, Malaspina, A, Marino, M.   +65 more
core   +2 more sources

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Nature Communications, 2020
Neuroimmune interactions are important in amyotrophic lateral sclerosis (ALS). Here the authors characterize the role of NK cells in mouse models of ALS, and in patient tissue.
Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard M. Ransohoff, Angela Santoni, Cristina Limatola   +11 more
doaj   +1 more source

Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)

eNeurologicalSci, 2020
Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan.
Peter S. Spencer, Valerie S. Palmer, Tameko Kihira, Sohei Yoshida, Jacques Reis, Momoko Yabushita, Yoshiro Yase   +6 more
doaj   +1 more source

Conditional associative learning examined in a paralyzed patient with amyotrophic lateral sclerosis using brain-computer interface technology [PDF]

, 2008
Background Brain-computer interface methodology based on self-regulation of slow-cortical potentials (SCPs) of the EEG (electroencephalogram) was used to assess conditional associative learning in one severely paralyzed, late-stage ALS patient.
Ghanayim, Nimr, J Kaiser, N Neumann, Iversen IH, Birbaumer N, Neumann, Nicola, Iversen, Iver H., Kaiser, Jochen, Kaiser J, Ghanayim N, Kübler, Andrea, Neumann N, N Birbaumer, N Ghanayim, IH Iversen, A Kübler, IH Iversen, Birbaumer, Niels, Kübler A   +18 more
core   +1 more source

Cognitive and Affective Symptoms of Amyotrophic Lateral Sclerosis: Clinical and Prognostic Aspects

Psychiatry International
Amyotrophic Lateral Sclerosis is a neurodegenerative disease characterized by progressive muscular impairment resulting in death, mainly from respiratory failure.
Leonardo Massoni
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source