Results 11 to 20 of about 95,709 (300)

Drug repurposing in amyotrophic lateral sclerosis (ALS). [PDF]

Expert Opin Drug Discov
Identifying treatments that can alter the natural history of amyotrophic lateral sclerosis (ALS) is challenging. For years, drug discovery in ALS has relied upon traditional approaches with limited success. Drug repurposing, where clinically approved drugs are reevaluated for other indications, offers an alternative strategy that overcomes some of the ...
Carroll E, Scaber J, Huber KVM, Brennan PE, Thompson AG, Turner MR, Talbot K.   +6 more
europepmc   +3 more sources

Motor Neuron Disease: The Contribution of TAR-43 Gene in Amyotrophic Lateral Sclerosis [PDF]

Bengal Physician Journal, 2023
Motor neuron diseases are a spectrum of neurodegenerative disorders, characterized by their physicochemical propinquity for the voluntary motor systems. The most notorious of these neurodegenerative disorders is amyotrophic lateral sclerosis (ALS), which
Gorky Guha
doaj   +1 more source

Investigating the Effectiveness of Acceptance and Commitment Therapy on Perceived Social Support and Life Expectancy of Caregivers of Patients with Amyotrophic Lateral Sclerosis (ALS): A Case Study [PDF]

مجله علوم پزشکی صدرا, 2023
Introduction: Caring for patients with amyotrophic lateral sclerosis (ALS) presents numerous challenges that can significantly impact caregivers. These challenges necessitate interventions to increase perceived social support and improve life expectancy.
Royasadat Shavaran, Akram Dehghani Champiri   +1 more
doaj   +1 more source

RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord [PDF]

, 2016
ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons.
A Al-Chalabi, A Chesi, A Dobin, A Hirano, A Kratz, A McKenna, A Saito, A Zhou, AB van Spriel, AE Renton, AM Bolger, AT Kwon, B Hoesel, B Ikiz, B Tian, B Zhang, C Cereda, C Figueroa-Romero, C Trapnell, Cedric Raoul, CG Saris, CM Higgins, CY Jin, D Brustolim, D Kim, D Kim, D Liu, D Nagy, D Schiffer, David G. Brohawn, DJ Park, ED Hall, EW Stommel, GA Van der Auwera, GN Babu, H Jeong, H Li, H Tanaka, IM Chiu, IR Holtman, J Ganesalingam, J Kong, J Satoh, James P. Bennett, JL Elliott, JS Henkel, JS Henkel, K Hattermann, K Hensley, KE Lewis, KM Mohler, L Probert, Laura C. O’Brien, LB Fanning, LC O'Brien, LJ Kogelman, M Damiano, M Hausmann, M Maschietto, M Mattiazzi, M Poloni, M Prudencio, MA DePristo, MD Robinson, ME Alexianu, ME Rusiniak, MG Hinds, MI Love, MJ Landrum, MR Turner, MW Amoroso, O Abel, O Hardiman, O Micheau, P Corcia, P Langfelder, PB Verghese, PD Stenson, PG Engstrom, PK Andrus, PR Heath, RJ Ferrante, S Abel, S Anders, S Byrne, S Hagl, S Horvath, S Khan, S Sasaki, S Sasaki, SL Carter, SN Dowey, SS Han, T Yoshihara, W Zhao, Y Chang, Y Ma, YJ Surh, Z Wang, ZH Zhang   +99 more
core   +21 more sources

High and Low Contrast Visual Acuity Are Not Affected in Amyotrophic Lateral Sclerosis. [PDF]

PLoS ONE, 2016
The afferent visual system may be affected by neuro-degeneration in amyotrophic lateral sclerosis (ALS) based on observations of visual function impairment and retinal inclusions on histopathology in ALS patients.
Heather E Moss, Monica Samelson, Girish Mohan, Qin Li Jiang   +3 more
doaj   +1 more source

Early Referral to an ALS Center Reduces Several Months the Diagnostic Delay: A Multicenter-Based Study

Frontiers in Neurology, 2020
Objective: To analyze those factors contributing to the diagnostic delay in ALS.Methods: Consecutive ALS patients were categorized as those studied in departmental hospitals and those studied in a referral ALS center.
Marina Martínez-Molina, Marina Martínez-Molina, Herminia Argente-Escrig, Herminia Argente-Escrig, Margarita F. Polo, David Hervás, Marina Frasquet, Marina Frasquet, Victoria Cortés, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa   +16 more
doaj   +1 more source

Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis

Data in Brief, 2020
A standardised, single-centre, longitudinal imaging protocol was used to evaluate longitudinal brainstem alterations in 100 patients with amyotrophic lateral sclerosis (ALS) with reference to 33 patients with primary lateral sclerosis (PLS), 30 patients ...
Peter Bede, Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Kai Ming Chang, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman   +11 more
doaj   +1 more source

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav, Mehta, Tejas, Sommers, Richard   +2 more
core   +2 more sources

Case report: A variant of the FIG4 gene with rapidly progressive amyotrophic lateral sclerosis

Frontiers in Neurology, 2022
Heterozygous autosomal-dominant FIG4 mutations are associated with amyotrophic lateral sclerosis (ALS). Here, we describe a variant of the FIG4 gene (c.350dupC, p.Asp118GlyfsTer9) in a patient with rapidly progressive ALS that has not previously been ...
Mubalake Yilihamu, Mubalake Yilihamu, Mubalake Yilihamu, Xiaolu Liu, Xiaolu Liu, Xiaolu Liu, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Yong Chen, Yong Chen, Yong Chen, Dongsheng Fan, Dongsheng Fan, Dongsheng Fan   +14 more
doaj   +1 more source

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis [PDF]

, 2020
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron degeneration in adults, and several mechanisms underlying the disease pathology have been proposed.
Christoforidou, Eleni, Hafezparast, Majid, Joilin, Greig   +2 more
core   +1 more source